Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study

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Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study. / Uddin, Md Jamal; Ekstrøm, Claus Thorn; Hemager, Nicoline; Christiani, Camilla A.J.; Gregersen, Maja; Ellersgaard, Ditte Vestbjerg; Spang, Katrine Søborg; Greve, Aja; Burton, Birgitte Klee; Søndergaard, Anne; Nudel, Ron; Mortensen, Preben Bo; Pedersen, Marianne Giørtz; Pedersen, Carsten Bøcker; Wang, Yunpeng; Werge, Thomas; Bybjerg-Grauholm, Jonas; Von Plessen, Kerstin J.; Bliksted, Vibeke; Mors, Ole; Thorup, Anne A.E.; Nordentoft, Merete.

In: Schizophrenia Bulletin Open, Vol. 2, No. 1, sgab024, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Uddin, MJ, Ekstrøm, CT, Hemager, N, Christiani, CAJ, Gregersen, M, Ellersgaard, DV, Spang, KS, Greve, A, Burton, BK, Søndergaard, A, Nudel, R, Mortensen, PB, Pedersen, MG, Pedersen, CB, Wang, Y, Werge, T, Bybjerg-Grauholm, J, Von Plessen, KJ, Bliksted, V, Mors, O, Thorup, AAE & Nordentoft, M 2021, 'Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study', Schizophrenia Bulletin Open, vol. 2, no. 1, sgab024. https://doi.org/10.1093/schizbullopen/sgab024

APA

Uddin, M. J., Ekstrøm, C. T., Hemager, N., Christiani, C. A. J., Gregersen, M., Ellersgaard, D. V., Spang, K. S., Greve, A., Burton, B. K., Søndergaard, A., Nudel, R., Mortensen, P. B., Pedersen, M. G., Pedersen, C. B., Wang, Y., Werge, T., Bybjerg-Grauholm, J., Von Plessen, K. J., Bliksted, V., ... Nordentoft, M. (2021). Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study. Schizophrenia Bulletin Open, 2(1), [sgab024]. https://doi.org/10.1093/schizbullopen/sgab024

Vancouver

Uddin MJ, Ekstrøm CT, Hemager N, Christiani CAJ, Gregersen M, Ellersgaard DV et al. Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study. Schizophrenia Bulletin Open. 2021;2(1). sgab024. https://doi.org/10.1093/schizbullopen/sgab024

Author

Uddin, Md Jamal ; Ekstrøm, Claus Thorn ; Hemager, Nicoline ; Christiani, Camilla A.J. ; Gregersen, Maja ; Ellersgaard, Ditte Vestbjerg ; Spang, Katrine Søborg ; Greve, Aja ; Burton, Birgitte Klee ; Søndergaard, Anne ; Nudel, Ron ; Mortensen, Preben Bo ; Pedersen, Marianne Giørtz ; Pedersen, Carsten Bøcker ; Wang, Yunpeng ; Werge, Thomas ; Bybjerg-Grauholm, Jonas ; Von Plessen, Kerstin J. ; Bliksted, Vibeke ; Mors, Ole ; Thorup, Anne A.E. ; Nordentoft, Merete. / Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study. In: Schizophrenia Bulletin Open. 2021 ; Vol. 2, No. 1.

Bibtex

@article{fb1210f4a8a345868cdc0d1018b42a42,

title = "Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study",

abstract = "We aimed to investigate to which degree the home environment and/or primary caregivers' level of functioning mediate the association between parental mental illness (eg, schizophrenia) and child psychopathology. We used data from the nationwide Danish High Risk and Resilience Study-VIA7. The study sample comprised 522 seven-year-old children. The main outcome was the child psychopathology, assessed with the Child Behavior Checklist (CBCL). The exposure variable had 3 categories: children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls. Mediators were quality of the Home Observation for Measurement of the Environment (HOME) and primary caregiver's Personal and Social Performance Scale (primary caregiver functioning). Primary caregiver's IQ and polygenic risk scores (PRS) for the educational attainment of the children were considered as covariates. We found a significant indirect adjusted effect of FHR status vs controls on CBCL total scores (FHR-SZ = 5.34, 95% confidence interval [CI]: 3.50-7.47 and FHR-BP = 4.54, 95% CI: 2.65-6.68), through primary caregiver functioning and HOME. Both mediators combined explained 53% and 64% variation of the total effects of FHR-SZ and FHR-BP, respectively. Adjusting for the PRS in the mediation models only resulted in minor changes in the FHR effects on the CBCL. We conclude that the HOME and the primary caregiver functioning are important mediating factors for child psychopathology, especially in children born with familial risk for severe mental illness. This knowledge may represent a window of opportunity for the development of preventive strategies (eg, intervention to improve primary caregiver functioning and home environment). ",

keywords = "child psychopathology, familial high risk, home environment, parental mental illness, primary caregiver's psychosocial functioning",

author = "Uddin, {Md Jamal} and Ekstr{\o}m, {Claus Thorn} and Nicoline Hemager and Christiani, {Camilla A.J.} and Maja Gregersen and Ellersgaard, {Ditte Vestbjerg} and Spang, {Katrine S{\o}borg} and Aja Greve and Burton, {Birgitte Klee} and Anne S{\o}ndergaard and Ron Nudel and Mortensen, {Preben Bo} and Pedersen, {Marianne Gi{\o}rtz} and Pedersen, {Carsten B{\o}cker} and Yunpeng Wang and Thomas Werge and Jonas Bybjerg-Grauholm and {Von Plessen}, {Kerstin J.} and Vibeke Bliksted and Ole Mors and Thorup, {Anne A.E.} and Merete Nordentoft",

note = "Publisher Copyright: {\textcopyright} 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center.",

year = "2021",

doi = "10.1093/schizbullopen/sgab024",

language = "English",

volume = "2",

journal = "Schizophrenia Bulletin Open",

issn = "2632-7899",

publisher = "Oxford University Press",

number = "1",

}

RIS

TY - JOUR

T1 - Is the Association between Parents' Mental Illness and Child Psychopathology Mediated via Home Environment and Caregiver's Psychosocial Functioning? A Mediation Analysis of the Danish High Risk and Resilience Study-VIA7, a Population-Based Cohort Study

AU - Uddin, Md Jamal

AU - Ekstrøm, Claus Thorn

AU - Hemager, Nicoline

AU - Christiani, Camilla A.J.

AU - Gregersen, Maja

AU - Ellersgaard, Ditte Vestbjerg

AU - Spang, Katrine Søborg

AU - Greve, Aja

AU - Burton, Birgitte Klee

AU - Søndergaard, Anne

AU - Nudel, Ron

AU - Mortensen, Preben Bo

AU - Pedersen, Marianne Giørtz

AU - Pedersen, Carsten Bøcker

AU - Wang, Yunpeng

AU - Werge, Thomas

AU - Bybjerg-Grauholm, Jonas

AU - Von Plessen, Kerstin J.

AU - Bliksted, Vibeke

AU - Mors, Ole

AU - Thorup, Anne A.E.

AU - Nordentoft, Merete

PY - 2021

Y1 - 2021

N2 - We aimed to investigate to which degree the home environment and/or primary caregivers' level of functioning mediate the association between parental mental illness (eg, schizophrenia) and child psychopathology. We used data from the nationwide Danish High Risk and Resilience Study-VIA7. The study sample comprised 522 seven-year-old children. The main outcome was the child psychopathology, assessed with the Child Behavior Checklist (CBCL). The exposure variable had 3 categories: children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls. Mediators were quality of the Home Observation for Measurement of the Environment (HOME) and primary caregiver's Personal and Social Performance Scale (primary caregiver functioning). Primary caregiver's IQ and polygenic risk scores (PRS) for the educational attainment of the children were considered as covariates. We found a significant indirect adjusted effect of FHR status vs controls on CBCL total scores (FHR-SZ = 5.34, 95% confidence interval [CI]: 3.50-7.47 and FHR-BP = 4.54, 95% CI: 2.65-6.68), through primary caregiver functioning and HOME. Both mediators combined explained 53% and 64% variation of the total effects of FHR-SZ and FHR-BP, respectively. Adjusting for the PRS in the mediation models only resulted in minor changes in the FHR effects on the CBCL. We conclude that the HOME and the primary caregiver functioning are important mediating factors for child psychopathology, especially in children born with familial risk for severe mental illness. This knowledge may represent a window of opportunity for the development of preventive strategies (eg, intervention to improve primary caregiver functioning and home environment).

AB - We aimed to investigate to which degree the home environment and/or primary caregivers' level of functioning mediate the association between parental mental illness (eg, schizophrenia) and child psychopathology. We used data from the nationwide Danish High Risk and Resilience Study-VIA7. The study sample comprised 522 seven-year-old children. The main outcome was the child psychopathology, assessed with the Child Behavior Checklist (CBCL). The exposure variable had 3 categories: children at familial high risk of schizophrenia spectrum psychosis (FHR-SZ), bipolar disorder (FHR-BP), and population-based controls. Mediators were quality of the Home Observation for Measurement of the Environment (HOME) and primary caregiver's Personal and Social Performance Scale (primary caregiver functioning). Primary caregiver's IQ and polygenic risk scores (PRS) for the educational attainment of the children were considered as covariates. We found a significant indirect adjusted effect of FHR status vs controls on CBCL total scores (FHR-SZ = 5.34, 95% confidence interval [CI]: 3.50-7.47 and FHR-BP = 4.54, 95% CI: 2.65-6.68), through primary caregiver functioning and HOME. Both mediators combined explained 53% and 64% variation of the total effects of FHR-SZ and FHR-BP, respectively. Adjusting for the PRS in the mediation models only resulted in minor changes in the FHR effects on the CBCL. We conclude that the HOME and the primary caregiver functioning are important mediating factors for child psychopathology, especially in children born with familial risk for severe mental illness. This knowledge may represent a window of opportunity for the development of preventive strategies (eg, intervention to improve primary caregiver functioning and home environment).

KW - child psychopathology

KW - familial high risk

KW - home environment

KW - parental mental illness

KW - primary caregiver's psychosocial functioning

U2 - 10.1093/schizbullopen/sgab024

DO - 10.1093/schizbullopen/sgab024

M3 - Journal article

AN - SCOPUS:85120788136

VL - 2

JO - Schizophrenia Bulletin Open

JF - Schizophrenia Bulletin Open

SN - 2632-7899

IS - 1

M1 - sgab024

ER -

ID: 305004232

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