Intrinsic molecules in lipid membranes change the lipid-domain interfacial area: cholesterol at domain interfaces
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Intrinsic molecules in lipid membranes change the lipid-domain interfacial area : cholesterol at domain interfaces. / Cruzeiro-Hansson, Leonor; Ipsen, John Hjort; Mouritsen, Ole G.
In: Biochimica et Biophysica Acta - Biomembranes, Vol. 979, No. 2, 1989, p. 166-176.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Intrinsic molecules in lipid membranes change the lipid-domain interfacial area
T2 - cholesterol at domain interfaces
AU - Cruzeiro-Hansson, Leonor
AU - Ipsen, John Hjort
AU - Mouritsen, Ole G.
PY - 1989
Y1 - 1989
N2 - A theoretical analysis of the effects of intrinsic molecules on the lateral density fluctuations in lipid bilayer membranes is carried out by means of computer simulations on a microscopic interaction model of the gel-to-fluid chain-melting phase transition. The inhomogeneous equilibrium structures of gel and fluid domains, which in previous work (Cruzerio-Hansson, L. and Mouritsen, O.G. (1988) Biochim. Biophys. Acta 944, 63-72) were shown to characterize the transition region of pure lipid membranes, are here shown to be enhanced by intrinsic molecules such as cholesterol. Cholesterol is found to increase the interfacial area and to accumulate in the interfaces. The interfacial area, the average cluster size, the lateral compressibility, and the membrane area are calculated as functions of temperature and cholesterol concentration. It is shown that the enhancement by cholesterol of the lateral density fluctuations and the lipid-domain interfacial area is most pronounced away from the transition temperature. The implications of the results are discussed in relation to passive ion permeability and function of interfacially active enzymes such as phospholipase.
AB - A theoretical analysis of the effects of intrinsic molecules on the lateral density fluctuations in lipid bilayer membranes is carried out by means of computer simulations on a microscopic interaction model of the gel-to-fluid chain-melting phase transition. The inhomogeneous equilibrium structures of gel and fluid domains, which in previous work (Cruzerio-Hansson, L. and Mouritsen, O.G. (1988) Biochim. Biophys. Acta 944, 63-72) were shown to characterize the transition region of pure lipid membranes, are here shown to be enhanced by intrinsic molecules such as cholesterol. Cholesterol is found to increase the interfacial area and to accumulate in the interfaces. The interfacial area, the average cluster size, the lateral compressibility, and the membrane area are calculated as functions of temperature and cholesterol concentration. It is shown that the enhancement by cholesterol of the lateral density fluctuations and the lipid-domain interfacial area is most pronounced away from the transition temperature. The implications of the results are discussed in relation to passive ion permeability and function of interfacially active enzymes such as phospholipase.
KW - Cholesterol
KW - Density fluctuation
KW - Heterogeneity
KW - Interface active molecule
KW - Lateral compressibility
KW - Lipid bilayer
KW - Phase transition
U2 - 10.1016/0005-2736(89)90432-X
DO - 10.1016/0005-2736(89)90432-X
M3 - Journal article
C2 - 2647144
AN - SCOPUS:0024503870
VL - 979
SP - 166
EP - 176
JO - B B A - Biomembranes
JF - B B A - Biomembranes
SN - 0005-2736
IS - 2
ER -
ID: 238387576