Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects: Using external exposure data to understand biomarker differences among countries
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Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects : Using external exposure data to understand biomarker differences among countries. / Smolders, R; Den Hond, E; Koppen, G; Govarts, E; Willems, H; Casteleyn, L; Kolossa-Gehring, M; Fiddicke, U; Castaño, A; Koch, H M; Angerer, J; Esteban, M; Sepai, O; Exley, K; Bloemen, L; Horvat, M; Knudsen, Lisbeth E.; Joas, A; Joas, R; Biot, P; Aerts, D; Katsonouri, A; Hadjipanayis, A; Cerna, M; Krskova, A; Schwedler, G; Seiwert, M; Nielsen, J K S; Rudnai, P; Közepesy, S; Evans, D S; Ryan, M P; Gutleb, A C; Fischer, M E; Ligocka, D; Jakubowski, M; Reis, M F; Namorado, S; Lupsa, I-R; Gurzau, A E; Halzlova, K; Fabianova, E; Mazej, D; Tratnik Snoj, J; Gomez, S; González, S; Berglund, M; Larsson, K; Lehmann, A; Crettaz, P; Schoeters, G.
In: Environmental Research, Vol. 141, 08.2015, p. 86–95.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interpreting biomarker data from the COPHES/DEMOCOPHES twin projects
T2 - Using external exposure data to understand biomarker differences among countries
AU - Smolders, R
AU - Den Hond, E
AU - Koppen, G
AU - Govarts, E
AU - Willems, H
AU - Casteleyn, L
AU - Kolossa-Gehring, M
AU - Fiddicke, U
AU - Castaño, A
AU - Koch, H M
AU - Angerer, J
AU - Esteban, M
AU - Sepai, O
AU - Exley, K
AU - Bloemen, L
AU - Horvat, M
AU - Knudsen, Lisbeth E.
AU - Joas, A
AU - Joas, R
AU - Biot, P
AU - Aerts, D
AU - Katsonouri, A
AU - Hadjipanayis, A
AU - Cerna, M
AU - Krskova, A
AU - Schwedler, G
AU - Seiwert, M
AU - Nielsen, J K S
AU - Rudnai, P
AU - Közepesy, S
AU - Evans, D S
AU - Ryan, M P
AU - Gutleb, A C
AU - Fischer, M E
AU - Ligocka, D
AU - Jakubowski, M
AU - Reis, M F
AU - Namorado, S
AU - Lupsa, I-R
AU - Gurzau, A E
AU - Halzlova, K
AU - Fabianova, E
AU - Mazej, D
AU - Tratnik Snoj, J
AU - Gomez, S
AU - González, S
AU - Berglund, M
AU - Larsson, K
AU - Lehmann, A
AU - Crettaz, P
AU - Schoeters, G
N1 - Copyright © 2014 Elsevier Inc. All rights reserved.
PY - 2015/8
Y1 - 2015/8
N2 - In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.
AB - In 2011 and 2012, the COPHES/DEMOCOPHES twin projects performed the first ever harmonized human biomonitoring survey in 17 European countries. In more than 1800 mother-child pairs, individual lifestyle data were collected and cadmium, cotinine and certain phthalate metabolites were measured in urine. Total mercury was determined in hair samples. While the main goal of the COPHES/DEMOCOPHES twin projects was to develop and test harmonized protocols and procedures, the goal of the current paper is to investigate whether the observed differences in biomarker values among the countries implementing DEMOCOPHES can be interpreted using information from external databases on environmental quality and lifestyle. In general, 13 countries having implemented DEMOCOPHES provided high-quality data from external sources that were relevant for interpretation purposes. However, some data were not available for reporting or were not in line with predefined specifications. Therefore, only part of the external information could be included in the statistical analyses. Nonetheless, there was a highly significant correlation between national levels of fish consumption and mercury in hair, the strength of antismoking legislation was significantly related to urinary cotinine levels, and we were able to show indications that also urinary cadmium levels were associated with environmental quality and food quality. These results again show the potential of biomonitoring data to provide added value for (the evaluation of) evidence-informed policy making.
U2 - 10.1016/j.envres.2014.08.016
DO - 10.1016/j.envres.2014.08.016
M3 - Journal article
C2 - 25440294
VL - 141
SP - 86
EP - 95
JO - Environmental Research
JF - Environmental Research
SN - 0013-9351
ER -
ID: 137757007