Interleukin-21 mRNA expression during virus infections
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Interleukin-21 mRNA expression during virus infections. / Holm, Christian; Nyvold, Charlotte Guldborg; Paludan, Søren Riis; Thomsen, Allan R; Hokland, Marianne.
In: Cytokine, Vol. 33, No. 1, 2006, p. 41-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Interleukin-21 mRNA expression during virus infections
AU - Holm, Christian
AU - Nyvold, Charlotte Guldborg
AU - Paludan, Søren Riis
AU - Thomsen, Allan R
AU - Hokland, Marianne
N1 - Keywords: Animals; Arenaviridae Infections; CD4-Positive T-Lymphocytes; Female; Herpes Genitalis; Herpesvirus 2, Human; Interferon-gamma; Interleukins; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; RNA, Messenger; Spleen; Time Factors
PY - 2006
Y1 - 2006
N2 - Interleukin-21 is a cytokine with profound impact on the proliferation and differentiation of activated leukocytes of both the innate and adaptive immune system. In experiments in vitro, antigen activation induces IL-21 production in CD4+ T cells. Where, when, and how the proliferative and activational effects of IL-21 on different leukocytes come into play in vivo in an immune response has so far not been fully investigated. We show here for the first time in vivo, that IL-21 mRNA is produced in the spleen when mice are challenged with herpes simplex virus type 2 (HSV-2) or lymphocytic choriomeningitis virus (LCMV). We show in HSV-2 challenged mice that this production takes place in CD4+ T cell fractions and is absent in CD4+ T cell-depleted fractions. We also show that the peak of IL-21 mRNA production in both the HSV-2 and LCMV-challenged mice coincides with the onset of the adaptive immune response. Thus, our data suggest a role for IL-21 in the early stages of adaptive immune response against virus infections.
AB - Interleukin-21 is a cytokine with profound impact on the proliferation and differentiation of activated leukocytes of both the innate and adaptive immune system. In experiments in vitro, antigen activation induces IL-21 production in CD4+ T cells. Where, when, and how the proliferative and activational effects of IL-21 on different leukocytes come into play in vivo in an immune response has so far not been fully investigated. We show here for the first time in vivo, that IL-21 mRNA is produced in the spleen when mice are challenged with herpes simplex virus type 2 (HSV-2) or lymphocytic choriomeningitis virus (LCMV). We show in HSV-2 challenged mice that this production takes place in CD4+ T cell fractions and is absent in CD4+ T cell-depleted fractions. We also show that the peak of IL-21 mRNA production in both the HSV-2 and LCMV-challenged mice coincides with the onset of the adaptive immune response. Thus, our data suggest a role for IL-21 in the early stages of adaptive immune response against virus infections.
U2 - 10.1016/j.cyto.2005.11.014
DO - 10.1016/j.cyto.2005.11.014
M3 - Journal article
C2 - 16406655
VL - 33
SP - 41
EP - 45
JO - Cytokine
JF - Cytokine
SN - 1043-4666
IS - 1
ER -
ID: 9701263