Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort
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Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort. / Hansen, Louise; Skeie, Guri; Landberg, Rikard; Lund, Eiliv; Palmqvist, Richard; Johansson, Ingegerd; Dragsted, Lars Ove; Egeberg, Rikke; Johnsen, Nina F; Christensen, Jane; Overvad, Kim; Tjønneland, Anne; Olsen, Anja.
In: International Journal of Cancer, Vol. 131, No. 2, 2012, p. 469-478.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Intake of dietary fiber, especially from cereal foods, is associated with lower incidence of colon cancer in the HELGA cohort
AU - Hansen, Louise
AU - Skeie, Guri
AU - Landberg, Rikard
AU - Lund, Eiliv
AU - Palmqvist, Richard
AU - Johansson, Ingegerd
AU - Dragsted, Lars Ove
AU - Egeberg, Rikke
AU - Johnsen, Nina F
AU - Christensen, Jane
AU - Overvad, Kim
AU - Tjønneland, Anne
AU - Olsen, Anja
N1 - IHE 2012 075
PY - 2012
Y1 - 2012
N2 - The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.
AB - The role of dietary fiber on the risk of colon and rectal cancer has been investigated in numerous studies, but findings have been inconsistent. The purpose of this study was to examine associations between intake of dietary fiber and risk of incident colon (including distal and proximal colon) and rectal cancer in the prospective Scandinavian HELGA cohort and to determine if fiber source (vegetables, fruits, potatoes, cereals) impacted the association. We included 1,168 incident cases (691 colon, 477 rectal cancer), diagnosed during a median of 11.3 years, among 108,081 cohort members. Sex-specific incidence rate ratios (IRRs) of colon and rectal cancer were related to intake of total or specific fiber source using Cox proportional hazards models. For men, an inverse association was observed between intake of total fiber and the risk of colon cancer per an incremental increase of 10 g day(-1) , IRR (95% CI): 0.74 (0.64-0.86). Intake of cereal fiber per 2 g day(-1) was associated with an IRR of 0.94 (0.91-0.98), which was also seen for intake of cereal fiber from foods with high fiber content (≥ 5 g per 100 g product), where the IRR per 2 g day(-1) was 0.94 (0.90-0.98). In women, intake of cereal fiber per 2 g day(-1) was also associated with lower risk of colon cancer, 0.97 (0.93-1.00). No clear associations were seen for rectal cancer. Our data indicate a protective role of total and cereal fiber intake, particularly from cereal foods with high fiber content, in the prevention of colon cancer.
KW - Adult
KW - Cereals
KW - Cohort Studies
KW - Colonic Neoplasms
KW - Dietary Fiber
KW - Eating
KW - Female
KW - Food Habits
KW - Fruit
KW - Humans
KW - Incidence
KW - Male
KW - Middle Aged
KW - Rectal Neoplasms
KW - Risk Factors
KW - Scandinavia
KW - Vegetables
U2 - 10.1002/ijc.26381
DO - 10.1002/ijc.26381
M3 - Journal article
C2 - 21866547
VL - 131
SP - 469
EP - 478
JO - International Journal of Cancer
JF - International Journal of Cancer
SN - 0020-7136
IS - 2
ER -
ID: 49107740