Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro

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Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro. / Hansen, Harald S.

In: Prostaglandins - Biology, Vol. 8, No. 2, 01.01.1974, p. 95-105.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hansen, HS 1974, 'Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro', Prostaglandins - Biology, vol. 8, no. 2, pp. 95-105.

APA

Hansen, H. S. (1974). Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro. Prostaglandins - Biology, 8(2), 95-105.

Vancouver

Hansen HS. Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro. Prostaglandins - Biology. 1974 Jan 1;8(2):95-105.

Author

Hansen, Harald S. / Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro. In: Prostaglandins - Biology. 1974 ; Vol. 8, No. 2. pp. 95-105.

Bibtex

@article{4bb81472131a476e96a00dbfaa12d7ce,
title = "Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro",
abstract = "15 Hydroxyprostaglandin dehydrogenase from bovine lung was purified 7.4 times to a specific activity of 1.4 mU/mg of protein. The isoelectric point was estimated at 5.4 and the molecular weight by gel filtration at 40,000. K(m) for prostaglandin E and for NAD was found to be 3.4 µM and 1.1 x 10M respectively. The enzyme was inhibited by indomethacin and aspirin. The indomethacin inhibition was found to be non competitive to prostaglandin E having a K(i) = 1.4 x 10M and a K'(i) = 1.6 x 10M.",
author = "Hansen, {Harald S.}",
year = "1974",
month = jan,
day = "1",
language = "English",
volume = "8",
pages = "95--105",
journal = "Prostaglandins - Biology",
issn = "0142-8284",
number = "2",

}

RIS

TY - JOUR

T1 - Inhibition by indomethacin and aspirin of 15 hydroxy prostaglandin dehydrogenase in vitro

AU - Hansen, Harald S.

PY - 1974/1/1

Y1 - 1974/1/1

N2 - 15 Hydroxyprostaglandin dehydrogenase from bovine lung was purified 7.4 times to a specific activity of 1.4 mU/mg of protein. The isoelectric point was estimated at 5.4 and the molecular weight by gel filtration at 40,000. K(m) for prostaglandin E and for NAD was found to be 3.4 µM and 1.1 x 10M respectively. The enzyme was inhibited by indomethacin and aspirin. The indomethacin inhibition was found to be non competitive to prostaglandin E having a K(i) = 1.4 x 10M and a K'(i) = 1.6 x 10M.

AB - 15 Hydroxyprostaglandin dehydrogenase from bovine lung was purified 7.4 times to a specific activity of 1.4 mU/mg of protein. The isoelectric point was estimated at 5.4 and the molecular weight by gel filtration at 40,000. K(m) for prostaglandin E and for NAD was found to be 3.4 µM and 1.1 x 10M respectively. The enzyme was inhibited by indomethacin and aspirin. The indomethacin inhibition was found to be non competitive to prostaglandin E having a K(i) = 1.4 x 10M and a K'(i) = 1.6 x 10M.

UR - http://www.scopus.com/inward/record.url?scp=0016295885&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0016295885

VL - 8

SP - 95

EP - 105

JO - Prostaglandins - Biology

JF - Prostaglandins - Biology

SN - 0142-8284

IS - 2

ER -

ID: 45273395