Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats
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Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats. / Olsen, Peter Skov; Boesby, S.; Kirkegaard, P.; Therkelsen, K; Almdal, Thomas; Poulsen, Steen Seier; Nexø, Ebba; Nexø, Ebba.
In: Hepatology, Vol. 8, No. 5, 2013, p. 992-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Influence of epidermal growth factor on liver regeneration after partial hepatectomy in rats
AU - Olsen, Peter Skov
AU - Boesby, S.
AU - Kirkegaard, P.
AU - Therkelsen, K
AU - Almdal, Thomas
AU - Poulsen, Steen Seier
AU - Nexø, Ebba
AU - Nexø, Ebba
PY - 2013
Y1 - 2013
N2 - The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated. After a 70% hepatectomy in rats, the concentration of epidermal growth factor in portal venous blood was unchanged compared with unoperated controls. However, small amounts of epidermal growth factor could be identified in portal venous blood after intestinal instillation of epidermal growth factor. Brunner's glands and the submandibular glands secrete epidermal growth factor. Extirpation of Brunner's glands decreased liver regeneration, whereas removal of the submandibular glands had no effect on liver regeneration. Epidermal growth factor antiserum reduced liver regeneration significantly. Oral or s.c. administration of epidermal growth factor had no effect on liver regeneration, whereas epidermal growth factor enhanced the effect of insulin and glucagon on liver regeneration. The results suggest that endogenous epidermal growth factor participates in stimulation of liver regeneration after partial hepatectomy in rats. Epidermal growth factor given together with insulin and glucagon had a synergistic effect on liver regeneration which suggests that liver regeneration in the rat is controlled by multiple regulatory peptides.
AB - The role of epidermal growth factor on liver regeneration after partial hepatectomy in rats was investigated. After a 70% hepatectomy in rats, the concentration of epidermal growth factor in portal venous blood was unchanged compared with unoperated controls. However, small amounts of epidermal growth factor could be identified in portal venous blood after intestinal instillation of epidermal growth factor. Brunner's glands and the submandibular glands secrete epidermal growth factor. Extirpation of Brunner's glands decreased liver regeneration, whereas removal of the submandibular glands had no effect on liver regeneration. Epidermal growth factor antiserum reduced liver regeneration significantly. Oral or s.c. administration of epidermal growth factor had no effect on liver regeneration, whereas epidermal growth factor enhanced the effect of insulin and glucagon on liver regeneration. The results suggest that endogenous epidermal growth factor participates in stimulation of liver regeneration after partial hepatectomy in rats. Epidermal growth factor given together with insulin and glucagon had a synergistic effect on liver regeneration which suggests that liver regeneration in the rat is controlled by multiple regulatory peptides.
KW - Animals
KW - DNA
KW - Duodenum
KW - Epidermal Growth Factor
KW - Glucagon
KW - Hepatectomy
KW - Insulin
KW - Liver
KW - Liver Regeneration
KW - Male
KW - Portal Vein
KW - Rats
KW - Rats, Inbred Strains
KW - Salivary Glands
KW - Time Factors
U2 - 10.1002/hep.1840080503
DO - 10.1002/hep.1840080503
M3 - Journal article
C2 - 3047041
VL - 8
SP - 992
EP - 996
JO - Hepatology
JF - Hepatology
SN - 0270-9139
IS - 5
ER -
ID: 47488331