Inflammatory markers of CHMP2B-mediated frontotemporal dementia
Research output: Contribution to journal › Journal article › Research › peer-review
Histopathological studies and animal models have suggested an inflammatory component in the pathomechanism of the CHMP2B associated frontotemporal dementia (FTD-3). In this cross-sectional study, serum and cerebrospinal fluid were analyzed for inflammatory markers in CHMP2B mutation carriers. Serum levels of CCL4 were increased throughout life. Serum levels of IL-15, CXCL10, CCL22 and TNF-α were significantly associated with cognitive decline, suggesting a peripheral inflammatory response to neurodegeneration. CSF levels of sTREM2 appeared to increase more rapidly with age in CHMP2B mutation carriers. The identification of a peripheral inflammatory response to disease progression supports the involvement of an inflammatory component in FTD-3.
Original language | English |
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Journal | Journal of Neuroimmunology |
Volume | 324 |
Pages (from-to) | 136-142 |
Number of pages | 7 |
ISSN | 0165-5728 |
DOIs | |
Publication status | Published - 2018 |
ID: 216975339