Increase in natural killer cell activity during diethylcarbamazine treatment of patients with filariasis
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Increase in natural killer cell activity during diethylcarbamazine treatment of patients with filariasis. / Pedersen, B K; Bygbjerg, Ib Christian; Svenson, M.
In: Acta Tropica, Vol. 44, No. 3, 01.09.1987, p. 353-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increase in natural killer cell activity during diethylcarbamazine treatment of patients with filariasis
AU - Pedersen, B K
AU - Bygbjerg, Ib Christian
AU - Svenson, M
PY - 1987/9/1
Y1 - 1987/9/1
N2 - Two patients, one with Bancroftian filariasis and the other with onchocerciasis, and two healthy controls were treated with diethylcarbamazine (DEC). The natural killer (NK) cell activity of the two patients increased during DEC treatment to 2.5 and 2.8 times, respectively, while that of the controls remained unchanged. We conclude that the augmentation of baseline NK cell activity, as well as interferon- and interleukin-2-enhanced NK cell activity seen in the patients, is not a direct effect of DEC, but is related to the reaction to DEC in lymphatic filariasis and onchocerciasis.
AB - Two patients, one with Bancroftian filariasis and the other with onchocerciasis, and two healthy controls were treated with diethylcarbamazine (DEC). The natural killer (NK) cell activity of the two patients increased during DEC treatment to 2.5 and 2.8 times, respectively, while that of the controls remained unchanged. We conclude that the augmentation of baseline NK cell activity, as well as interferon- and interleukin-2-enhanced NK cell activity seen in the patients, is not a direct effect of DEC, but is related to the reaction to DEC in lymphatic filariasis and onchocerciasis.
KW - Adult
KW - Animals
KW - Diethylcarbamazine
KW - Elephantiasis, Filarial
KW - Female
KW - Filariasis
KW - Humans
KW - Killer Cells, Natural
KW - Male
KW - Middle Aged
KW - Onchocerciasis
M3 - Journal article
C2 - 2892372
VL - 44
SP - 353
EP - 355
JO - Acta Tropica
JF - Acta Tropica
SN - 0001-706X
IS - 3
ER -
ID: 33891637