Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure
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Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure. / Magkos, Faidon; Tsekouras, Yannis; Kavouras, Stavros A; Mittendorfer, Bettina; Sidossis, Labros S.
In: Clinical Science, Vol. 114, No. 1, 2008, p. 59-64.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure
AU - Magkos, Faidon
AU - Tsekouras, Yannis
AU - Kavouras, Stavros A
AU - Mittendorfer, Bettina
AU - Sidossis, Labros S
N1 - (Ekstern)
PY - 2008
Y1 - 2008
N2 - A single bout of moderate-intensity exercise increases whole-body insulin sensitivity for 12-48 h post-exercise; however, the relationship between exercise energy expenditure and the improvement in insulin sensitivity is not known. We hypothesized that the exercise-induced increase in whole-body insulin sensitivity, assessed with HOMAIR (homoeostasis model assessment of insulin resistance), is directly related to the energy expended during exercise. We studied 30 recreationally active non-obese men (age, 27+/-5 years; body mass index, 24+/-2 kg/m2) in the post-absorptive state on two separate occasions: once after exercising at 60% of VO22peak (peak oxygen consumption) for 30-120 min on the preceding afternoon (expending a total of 1.28-5.76 MJ) and once after an equivalent period of rest. Blood samples were obtained the following morning. Exercise-induced changes in HOMAIR were curvilinearly related to exercise energy expenditure (r=-0.666, P=0.001) with a threshold of approx. 3.77 MJ (900 kcal) for improvements in HOMAIR to be manifested. In particular, HOMAIR was reduced by 32+/-24% (P=0.003) in subjects who expended more than 3.77 MJ during exercise, but did not change for those who expended fewer than 3.77 MJ (-2+/-21%; P=0.301). Furthermore, the magnitude of change in HOMAIR after exercise was directly associated with baseline (i.e. resting) HOMAIR (r=-0.508, P=0.004); this relationship persisted in multivariate analysis. We conclude that improved whole-body insulin resistance after a single bout of exercise is curvilinearly related to exercise energy expenditure, and requires unfeasible amounts of exercise for most sedentary individuals.
AB - A single bout of moderate-intensity exercise increases whole-body insulin sensitivity for 12-48 h post-exercise; however, the relationship between exercise energy expenditure and the improvement in insulin sensitivity is not known. We hypothesized that the exercise-induced increase in whole-body insulin sensitivity, assessed with HOMAIR (homoeostasis model assessment of insulin resistance), is directly related to the energy expended during exercise. We studied 30 recreationally active non-obese men (age, 27+/-5 years; body mass index, 24+/-2 kg/m2) in the post-absorptive state on two separate occasions: once after exercising at 60% of VO22peak (peak oxygen consumption) for 30-120 min on the preceding afternoon (expending a total of 1.28-5.76 MJ) and once after an equivalent period of rest. Blood samples were obtained the following morning. Exercise-induced changes in HOMAIR were curvilinearly related to exercise energy expenditure (r=-0.666, P=0.001) with a threshold of approx. 3.77 MJ (900 kcal) for improvements in HOMAIR to be manifested. In particular, HOMAIR was reduced by 32+/-24% (P=0.003) in subjects who expended more than 3.77 MJ during exercise, but did not change for those who expended fewer than 3.77 MJ (-2+/-21%; P=0.301). Furthermore, the magnitude of change in HOMAIR after exercise was directly associated with baseline (i.e. resting) HOMAIR (r=-0.508, P=0.004); this relationship persisted in multivariate analysis. We conclude that improved whole-body insulin resistance after a single bout of exercise is curvilinearly related to exercise energy expenditure, and requires unfeasible amounts of exercise for most sedentary individuals.
KW - Adult
KW - Blood Glucose/metabolism
KW - Energy Metabolism/physiology
KW - Exercise/physiology
KW - Fasting/blood
KW - Homeostasis/physiology
KW - Humans
KW - Insulin/blood
KW - Insulin Resistance/physiology
KW - Male
KW - Oxygen Consumption/physiology
U2 - 10.1042/CS20070134
DO - 10.1042/CS20070134
M3 - Journal article
C2 - 17635103
VL - 114
SP - 59
EP - 64
JO - Clinical Science
JF - Clinical Science
SN - 0143-5221
IS - 1
ER -
ID: 297124801