Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark–a region wide study
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Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark–a region wide study. / Bollerup, Signe; Hallager, Sofie; Baek, Ole; Krarup, Henrik; Madsen, Lone Galmstrup; Thielsen, Peter; Balslev, Ulla; Mens, Helene; Barfod, Toke; Rye Clausen, Mette; Hobolth, Lise; Gerstoft, Jan; Weis, Nina.
In: Scandinavian Journal of Gastroenterology, Vol. 55, No. 7, 2020, p. 843-847.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Implementation of treatment recommendations for chronic hepatitis B in patients attending specialized hospital care in Denmark–a region wide study
AU - Bollerup, Signe
AU - Hallager, Sofie
AU - Baek, Ole
AU - Krarup, Henrik
AU - Madsen, Lone Galmstrup
AU - Thielsen, Peter
AU - Balslev, Ulla
AU - Mens, Helene
AU - Barfod, Toke
AU - Rye Clausen, Mette
AU - Hobolth, Lise
AU - Gerstoft, Jan
AU - Weis, Nina
PY - 2020
Y1 - 2020
N2 - Objective: To evaluate implementation of national guideline recommendations on treatment initiation for chronic hepatitis B (CHB) in Denmark. Methods: Using DANHEP, a nationwide cohort of chronic hepatitis B and C patients attending specialized hospital care in Denmark, we performed a descriptive cohort study from January 2002 through December 2017. We identified patients with CHB in 3 of 5 Danish regions, with at least two hospital/outpatient clinic visits during the study period. Results: We identified 990 CHB patients who remained untreated throughout the study period, and 265 who initiated treatment. At their last visit 952/990 (96%, 95% CI 95–97) untreated patients did not meet current national criteria for treatment initiation while 198/265 (75%, 95% CI 69–80) who initiated treatment met the national criteria. Overall, 198/236 (84%, 95% CI 79–88) who met national treatment criteria, initiated treatment. Conclusion: The majority of CHB patients received care in line with national guideline recommendations for treatment initiation. We found that only few patients eligible for treatment remained untreated. However, a fourth of patients who received treatment were not eligible according to national guidelines.
AB - Objective: To evaluate implementation of national guideline recommendations on treatment initiation for chronic hepatitis B (CHB) in Denmark. Methods: Using DANHEP, a nationwide cohort of chronic hepatitis B and C patients attending specialized hospital care in Denmark, we performed a descriptive cohort study from January 2002 through December 2017. We identified patients with CHB in 3 of 5 Danish regions, with at least two hospital/outpatient clinic visits during the study period. Results: We identified 990 CHB patients who remained untreated throughout the study period, and 265 who initiated treatment. At their last visit 952/990 (96%, 95% CI 95–97) untreated patients did not meet current national criteria for treatment initiation while 198/265 (75%, 95% CI 69–80) who initiated treatment met the national criteria. Overall, 198/236 (84%, 95% CI 79–88) who met national treatment criteria, initiated treatment. Conclusion: The majority of CHB patients received care in line with national guideline recommendations for treatment initiation. We found that only few patients eligible for treatment remained untreated. However, a fourth of patients who received treatment were not eligible according to national guidelines.
KW - adherence
KW - antiviral therapy
KW - Chronic hepatitis B
KW - Denmark
KW - guideline implementation
KW - recommendations
U2 - 10.1080/00365521.2020.1779803
DO - 10.1080/00365521.2020.1779803
M3 - Journal article
C2 - 32568561
AN - SCOPUS:85087291572
VL - 55
SP - 843
EP - 847
JO - Scandinavian Journal of Gastroenterology
JF - Scandinavian Journal of Gastroenterology
SN - 0036-5521
IS - 7
ER -
ID: 250979039