Impaired virus control and severe CD8+ T-cell-mediated immunopathology in chimeric mice deficient in gamma interferon receptor expression on both parenchymal and hematopoietic cells
Research output: Contribution to journal › Journal article › Research › peer-review
Bone marrow chimeras were used to determine the cellular target(s) for the antiviral activity of gamma interferon (IFN-gamma). By transfusing such mice with high numbers of naive virus-specific CD8(+) T cells, a system was created in which the majority of virus-specific CD8(+) T cells would be capable of responding to IFN-gamma, but expression of the relevant receptor on non-T cells could be experimentally controlled. Only when the IFN-gamma receptor is absent on both radioresistant parenchymal and bone marrow-derived cells will chimeric mice challenged with a highly invasive, noncytolytic virus completely lack the ability to control the infection and develop severe wasting disease. Further, the study shows that IFN-gamma receptor expression on parenchymal cells in the viscera is more important for virus control than IFN-gamma receptor expression on bone marrow-derived cells.
Original language | English |
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Journal | Journal of Virology |
Volume | 79 |
Issue number | 15 |
Pages (from-to) | 10073-6 |
Number of pages | 3 |
ISSN | 0022-538X |
DOIs | |
Publication status | Published - 2005 |
Bibliographical note
Keywords: Animals; Arenaviridae Infections; Bone Marrow Cells; CD8-Positive T-Lymphocytes; Chimera; Liver; Lymphocytic choriomeningitis virus; Mice; Mice, Inbred C57BL; Mice, Knockout; Receptors, Interferon; Spleen; Wasting Syndrome
ID: 9639229