Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis. / Madsbad, S; Bjerregaard, B; Henriksen, Jens Henrik Sahl; Juhl, E; Kehlet, H.
In: Gut, Vol. 21, No. 1, 1980, p. 52-6.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Impaired conversion of prednisone to prednisolone in patients with liver cirrhosis
AU - Madsbad, S
AU - Bjerregaard, B
AU - Henriksen, Jens Henrik Sahl
AU - Juhl, E
AU - Kehlet, H
N1 - Keywords: Administration, Oral; Adult; Female; Humans; Kinetics; Liver Cirrhosis; Liver Function Tests; Male; Middle Aged; Prednisolone; Prednisone
PY - 1980
Y1 - 1980
N2 - Fourteen patients with liver cirrhosis received oral prednisone or prednisolone (0.3 mg per kg) randomised on two consecutive days. Serum prednisone and prednisolone were measured over the following four hours. Mean serum prednisolone concentration after oral prednisone decreased with impaired liver function estimated by galactose elimination capacity (r = 0.64, P less than 0.03). Mean serum prednisolone concentration after oral prednisone in the seven patients with severely impaired liver function was only 53% (P less than 0.05) of that observed in the seven patients with slightly impaired liver function. Conversely, mean serum prednisone concentration after oral prednisone in the patients with severely impaired liver function was 74% higher (P = 0.05) than in patients with slightly impaired liver function. Mean serum prednisolone after oral prednisolone was independent of liver function. As only prednisolone exerts glucocorticoid activity, our results indicate that prednisolone should be preferred to prednisone in the treatment of patients with impaired liver function.
AB - Fourteen patients with liver cirrhosis received oral prednisone or prednisolone (0.3 mg per kg) randomised on two consecutive days. Serum prednisone and prednisolone were measured over the following four hours. Mean serum prednisolone concentration after oral prednisone decreased with impaired liver function estimated by galactose elimination capacity (r = 0.64, P less than 0.03). Mean serum prednisolone concentration after oral prednisone in the seven patients with severely impaired liver function was only 53% (P less than 0.05) of that observed in the seven patients with slightly impaired liver function. Conversely, mean serum prednisone concentration after oral prednisone in the patients with severely impaired liver function was 74% higher (P = 0.05) than in patients with slightly impaired liver function. Mean serum prednisolone after oral prednisolone was independent of liver function. As only prednisolone exerts glucocorticoid activity, our results indicate that prednisolone should be preferred to prednisone in the treatment of patients with impaired liver function.
M3 - Journal article
C2 - 7364321
VL - 21
SP - 52
EP - 56
JO - Gut
JF - Gut
SN - 0017-5749
IS - 1
ER -
ID: 19398588