Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis

Research output: Contribution to journal › Letter › Research › peer-review

Standard

Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis. / Buch, Anastasia S; Schjerling, Peter; Kjaer, Marie; Jorgensen, Lars Nannestad; Krarup, Peter-Martin; Ågren, Magnus S.

In: Wound Repair and Regeneration, Vol. 25, No. 3, 05.2017, p. 532-535.

Research output: Contribution to journal › Letter › Research › peer-review

Harvard

Buch, AS, Schjerling, P, Kjaer, M, Jorgensen, LN, Krarup, P-M & Ågren, MS 2017, 'Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis', Wound Repair and Regeneration, vol. 25, no. 3, pp. 532-535. https://doi.org/10.1111/wrr.12535

APA

Buch, A. S., Schjerling, P., Kjaer, M., Jorgensen, L. N., Krarup, P-M., & Ågren, M. S. (2017). Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis. Wound Repair and Regeneration, 25(3), 532-535. https://doi.org/10.1111/wrr.12535

Vancouver

Buch AS, Schjerling P, Kjaer M, Jorgensen LN, Krarup P-M, Ågren MS. Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis. Wound Repair and Regeneration. 2017 May;25(3):532-535. https://doi.org/10.1111/wrr.12535

Author

Buch, Anastasia S ; Schjerling, Peter ; Kjaer, Marie ; Jorgensen, Lars Nannestad ; Krarup, Peter-Martin ; Ågren, Magnus S. / Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis. In: Wound Repair and Regeneration. 2017 ; Vol. 25, No. 3. pp. 532-535.

Bibtex

@article{b71ff2389c164dfca59cb4694c4d6db2,
title = "Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis",
abstract = "The underlying molecular mechanisms for anastomotic leakage (AL) after colorectal surgery are unknown and there are no therapeutics for AL prevention. Our aim was to correlate endogenous matrix metalloproteinase (MMP) activity, collagen concentration, and collagen/MMP/cytokine mRNA levels with anatomic location in human colorectal tissue. We enrolled 22 patients in this prospective study: 7 underwent elective laparoscopic sigmoid resection and 15 underwent low anterior resection for colorectal cancer. Full-thickness intestinal tissue rings from anastomoses constructed with a circular stapler were used for the determination of the MMP activity, tissue collagen concentration and mRNA levels. COL1A1 (p = 0.017) and COL3A1 (p = 0.0013) mRNA levels were lower in rectal tissue than in colonic samples. Neither MMP activities nor collagen concentrations differed significantly between the two anatomic locations. By elucidating the factors responsible for the decreased collagen production we may identify specific molecular targets in AL prophylaxis.",
keywords = "Journal Article",
author = "Buch, {Anastasia S} and Peter Schjerling and Marie Kjaer and Jorgensen, {Lars Nannestad} and Peter-Martin Krarup and {\AA}gren, {Magnus S}",
note = "{\textcopyright} 2017 by the Wound Healing Society.",
year = "2017",
month = may,
doi = "10.1111/wrr.12535",
language = "English",
volume = "25",
pages = "532--535",
journal = "Wound Repair and Regeneration",
issn = "1067-1927",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - Impaired collagen synthesis in the rectum may be a molecular target in anastomotic leakage prophylaxis

AU - Buch, Anastasia S

AU - Schjerling, Peter

AU - Kjaer, Marie

AU - Jorgensen, Lars Nannestad

AU - Krarup, Peter-Martin

AU - Ågren, Magnus S

N1 - © 2017 by the Wound Healing Society.

PY - 2017/5

Y1 - 2017/5

N2 - The underlying molecular mechanisms for anastomotic leakage (AL) after colorectal surgery are unknown and there are no therapeutics for AL prevention. Our aim was to correlate endogenous matrix metalloproteinase (MMP) activity, collagen concentration, and collagen/MMP/cytokine mRNA levels with anatomic location in human colorectal tissue. We enrolled 22 patients in this prospective study: 7 underwent elective laparoscopic sigmoid resection and 15 underwent low anterior resection for colorectal cancer. Full-thickness intestinal tissue rings from anastomoses constructed with a circular stapler were used for the determination of the MMP activity, tissue collagen concentration and mRNA levels. COL1A1 (p = 0.017) and COL3A1 (p = 0.0013) mRNA levels were lower in rectal tissue than in colonic samples. Neither MMP activities nor collagen concentrations differed significantly between the two anatomic locations. By elucidating the factors responsible for the decreased collagen production we may identify specific molecular targets in AL prophylaxis.

AB - The underlying molecular mechanisms for anastomotic leakage (AL) after colorectal surgery are unknown and there are no therapeutics for AL prevention. Our aim was to correlate endogenous matrix metalloproteinase (MMP) activity, collagen concentration, and collagen/MMP/cytokine mRNA levels with anatomic location in human colorectal tissue. We enrolled 22 patients in this prospective study: 7 underwent elective laparoscopic sigmoid resection and 15 underwent low anterior resection for colorectal cancer. Full-thickness intestinal tissue rings from anastomoses constructed with a circular stapler were used for the determination of the MMP activity, tissue collagen concentration and mRNA levels. COL1A1 (p = 0.017) and COL3A1 (p = 0.0013) mRNA levels were lower in rectal tissue than in colonic samples. Neither MMP activities nor collagen concentrations differed significantly between the two anatomic locations. By elucidating the factors responsible for the decreased collagen production we may identify specific molecular targets in AL prophylaxis.

KW - Journal Article

U2 - 10.1111/wrr.12535

DO - 10.1111/wrr.12535

M3 - Letter

C2 - 28371122

VL - 25

SP - 532

EP - 535

JO - Wound Repair and Regeneration

JF - Wound Repair and Regeneration

SN - 1067-1927

IS - 3

ER -

ID: 186908904