Impact of xanthohumol (a prenylated flavonoid from hops) on DNA stability and other health-related biochemical parameters: Results of human intervention trials
Research output: Contribution to journal › Journal article › Research › peer-review
SCOPE: Xanthohumol (XN) is a hop flavonoid found in beers and refreshment drinks. Results of in vitro and animal studies indicate that it causes beneficial health effects due to DNA protective, anti-inflammatory, antioxidant, and phytoestrogenic properties. Aim of the present study was to find out if XN causes alterations of health-related parameters in humans.
METHODS AND RESULTS: The effects of the flavonoid were investigated in a randomized crossover intervention trial (n = 22) in which the participants consumed a XN drink (12 mg XN/P/day). We monitored alterations of the DNA stability in single cell gel electrophoresis assays in lymphocytes and of several health-related biomarkers. A decrease of oxidatively damaged purines and protection toward reactive oxygen species induced DNA damage was found after the consumption of the beverage; also the excretion of 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-guanosine in urine was reduced. The assumption that the flavonoid causes DNA protection was confirmed in a randomized follow-up study with pure XN (n = 10) with a parallel design. Other biochemical parameters reflecting the redox- and hormonal status and lipid- and glucose metabolism were not altered after the intervention.
CONCLUSION: Taken together, our data indicate that low doses of XN protect humans against oxidative DNA damage.
Original language | English |
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Journal | Molecular Nutrition & Food Research |
Volume | 60 |
Issue number | 4 |
Pages (from-to) | 773-86 |
Number of pages | 14 |
ISSN | 1613-4125 |
DOIs | |
Publication status | Published - Apr 2016 |
- Adult, DNA, DNA Damage, Deoxyguanosine, Female, Flavonoids, Humans, Male, Propiophenones, Protective Agents, Single-Cell Analysis, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Research areas
ID: 177066439