Impact of follow-up consultations for ICU survivors on post-ICU syndrome: a systematic review and meta-analysis
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Impact of follow-up consultations for ICU survivors on post-ICU syndrome : a systematic review and meta-analysis. / Jensen, J. F. ; Thomsen, Thordis; Overgaard, D; Bestle, Morten Heiberg; Christensen, Doris; Egerod, I.
In: Intensive Care Medicine, Vol. 41, No. 5, 05.2015, p. 763-75.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Impact of follow-up consultations for ICU survivors on post-ICU syndrome
T2 - a systematic review and meta-analysis
AU - Jensen, J. F.
AU - Thomsen, Thordis
AU - Overgaard, D
AU - Bestle, Morten Heiberg
AU - Christensen, Doris
AU - Egerod, I
PY - 2015/5
Y1 - 2015/5
N2 - PURPOSE: To evaluate the impact of routine follow-up consultations versus standard of care for intensive care unit (ICU) survivors.METHODS: Systematic literature review from five databases (Cochrane CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL), reference lists, citation tracking, and ongoing/unpublished trials. Randomized controlled trials investigating post-ICU consultations in adults with outcomes such as quality of life (QOL), anxiety, depression, posttraumatic stress disorder (PTSD), physical ability, cognitive function, and return to work were included. Two reviewers extracted data and assessed quality independently. The mean differences, risk ratios, and 95 % confidence intervals were calculated depending on outcome measures.RESULTS: From 1544 citations, five trials were included (855 patients). The overall risk of bias was low in two trials, unclear in two trials, and high in one trial. The overall quality of evidence was low. The trials assessed follow-up interventions defined as consultations informing survivors about their ICU stay. One trial found no effect on QOL. Pooling data from two trials (n = 374) showed a protective effect on risk of new onset PTSD at 3-6 months after ICU (risk ratio 0.49, 95 % CI 0.26-0.95). There was no effect on other outcomes.CONCLUSIONS: The evidence indicates that follow-up consultations might reduce symptoms of PTSD at 3-6 months after ICU discharge in ICU survivors, but without affecting QOL and other outcomes investigated. This review highlights that planning of future RCTs should aim to standardize interventions and outcome measures to allow for comparisons across studies.
AB - PURPOSE: To evaluate the impact of routine follow-up consultations versus standard of care for intensive care unit (ICU) survivors.METHODS: Systematic literature review from five databases (Cochrane CENTRAL, MEDLINE, EMBASE, PsycINFO, CINAHL), reference lists, citation tracking, and ongoing/unpublished trials. Randomized controlled trials investigating post-ICU consultations in adults with outcomes such as quality of life (QOL), anxiety, depression, posttraumatic stress disorder (PTSD), physical ability, cognitive function, and return to work were included. Two reviewers extracted data and assessed quality independently. The mean differences, risk ratios, and 95 % confidence intervals were calculated depending on outcome measures.RESULTS: From 1544 citations, five trials were included (855 patients). The overall risk of bias was low in two trials, unclear in two trials, and high in one trial. The overall quality of evidence was low. The trials assessed follow-up interventions defined as consultations informing survivors about their ICU stay. One trial found no effect on QOL. Pooling data from two trials (n = 374) showed a protective effect on risk of new onset PTSD at 3-6 months after ICU (risk ratio 0.49, 95 % CI 0.26-0.95). There was no effect on other outcomes.CONCLUSIONS: The evidence indicates that follow-up consultations might reduce symptoms of PTSD at 3-6 months after ICU discharge in ICU survivors, but without affecting QOL and other outcomes investigated. This review highlights that planning of future RCTs should aim to standardize interventions and outcome measures to allow for comparisons across studies.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Anxiety
KW - Cognition
KW - Critical Care
KW - Female
KW - Follow-Up Studies
KW - Humans
KW - Male
KW - Middle Aged
KW - Outcome Assessment (Health Care)
KW - Quality of Life
KW - Stress Disorders, Post-Traumatic
KW - Survivors
U2 - 10.1007/s00134-015-3689-1
DO - 10.1007/s00134-015-3689-1
M3 - Journal article
C2 - 25731633
VL - 41
SP - 763
EP - 775
JO - European Journal of Intensive Care Medicine
JF - European Journal of Intensive Care Medicine
SN - 0935-1701
IS - 5
ER -
ID: 161192058