Immune complex-associated thrombocytopenic purpura syndrome in sexually mature Göttingen minipigs
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Immune complex-associated thrombocytopenic purpura syndrome in sexually mature Göttingen minipigs. / Carrasco, L; Madsen, L W; Salguero, F J; Núñez, A; Sánchez-Cordón, P; Bollen, P.
In: Journal of Comparative Pathology, Vol. 128, No. 1, 2003, p. 25-32.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Immune complex-associated thrombocytopenic purpura syndrome in sexually mature Göttingen minipigs
AU - Carrasco, L
AU - Madsen, L W
AU - Salguero, F J
AU - Núñez, A
AU - Sánchez-Cordón, P
AU - Bollen, P
N1 - Copyright 2002 Elsevier Science Ltd.
PY - 2003
Y1 - 2003
N2 - Eleven cases of thrombocytopenic purpura (TP) in sexually mature male or female Göttingen minipigs occurred sporadically over 3 1/2 years in a closed breeding colony protected by strict barrier conditions. Typical clinical signs of TP, including extensive subcutaneous haemorrhages, were seen in all affected animals. Haematological abnormalities included marked thrombocytopenia and anaemia. A consistent histopathological finding was the presence of membranoproliferative lesions in the renal glomeruli. Immunohistochemically, glomerular deposits were positively labelled for complement factor C1q and often also for immunoglobulins. Bone marrow findings consisting of increased numbers of immature and apoptotic megakaryocytes were compatible with a state of increased platelet consumption. Based on the combined presence of thrombocytopenia and renal immune complexes, it is suggested that the syndrome was related to a type III hypersensitivity reaction. However, further studies are needed to verify this hypothesis.
AB - Eleven cases of thrombocytopenic purpura (TP) in sexually mature male or female Göttingen minipigs occurred sporadically over 3 1/2 years in a closed breeding colony protected by strict barrier conditions. Typical clinical signs of TP, including extensive subcutaneous haemorrhages, were seen in all affected animals. Haematological abnormalities included marked thrombocytopenia and anaemia. A consistent histopathological finding was the presence of membranoproliferative lesions in the renal glomeruli. Immunohistochemically, glomerular deposits were positively labelled for complement factor C1q and often also for immunoglobulins. Bone marrow findings consisting of increased numbers of immature and apoptotic megakaryocytes were compatible with a state of increased platelet consumption. Based on the combined presence of thrombocytopenia and renal immune complexes, it is suggested that the syndrome was related to a type III hypersensitivity reaction. However, further studies are needed to verify this hypothesis.
KW - Anemia/etiology
KW - Animals
KW - Antigen-Antibody Complex/immunology
KW - Cell Count/veterinary
KW - Complement C1q/analysis
KW - Female
KW - Glomerulonephritis, Membranoproliferative/complications
KW - Hemorrhage/etiology
KW - Immune Complex Diseases/complications
KW - Immunoenzyme Techniques/veterinary
KW - Immunoglobulins/analysis
KW - Kidney Glomerulus/chemistry
KW - Male
KW - Megakaryocytes/pathology
KW - Purpura, Thrombocytopenic/complications
KW - Sexual Maturation
KW - Swine
KW - Swine Diseases/immunology
KW - Swine, Miniature/immunology
KW - Syndrome
U2 - 10.1053/jcpa.2002.0601
DO - 10.1053/jcpa.2002.0601
M3 - Journal article
C2 - 12531684
VL - 128
SP - 25
EP - 32
JO - Journal of Comparative Pathology
JF - Journal of Comparative Pathology
SN - 0021-9975
IS - 1
ER -
ID: 324129252