Hypercalcaemia discrimination index: a multivariate analysis of parathyroid function in 107 hypercalcaemic patients
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Hypercalcaemia discrimination index : a multivariate analysis of parathyroid function in 107 hypercalcaemic patients. / Transbøl, I.; Schønau Jørgensen, F.; Hornum, I.; Keiding, N.
In: Acta Endocrinologica, Vol. 86, No. 4, 12.1977, p. 768-783.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Hypercalcaemia discrimination index
T2 - a multivariate analysis of parathyroid function in 107 hypercalcaemic patients
AU - Transbøl, I.
AU - Schønau Jørgensen, F.
AU - Hornum, I.
AU - Keiding, N.
PY - 1977/12
Y1 - 1977/12
N2 - The limited usefulness of radioimmunoassays of parathyroid hormone in the differential diagnosis of hypercalcaemia invites the use of methods measuring effects of parathyroid hormone (PTH). Data from 4-5-day metabolic studies in 107 hypercalcaemic patients (78 retrospective and 20 prospective cases) were combined in a hypercalcaemia discrimination index (HDI). HDI = (urine calcium (mg/24 h) x 100 x serum phosphate (mg/100 ml))/(serum total calcium (mg/100 ml)x 24-h clearance of creatinine (ml/min)) expresses in one figure the combined actions of PTH on the renal handling of calcium and on serum phosphate. A multivariate analysis confirmed that HDI offered optimal discrimination. An identical discrimination was observed in the prospective series. In the complete series HDI = 137 was the optimal discrimination point. Classification of the patients as having hyperparathyroidism (HPT) or pseudohyperparathyroidism (P-HPT) (<137) or non-parathyroid hypercalcaemia (NON-PTH) (≥ 137) corresponded in 100 out of 107 patients (93.5%) with the final clinical diagnosis. The effects on HDI of sex, age, season, urine losses, high calcium intake and use of thiazides were also evaluated. HDI appears to be a valuable tool in the endocrine evaluation of hypercalcaemic patients. Used in combination with radioimmunoassays measuring genuine but not ectopic PTH HDI may serve to classify hypercalcaemic patients within the following 3 subgroups: HPT, P-HPT and NON-PTH.
AB - The limited usefulness of radioimmunoassays of parathyroid hormone in the differential diagnosis of hypercalcaemia invites the use of methods measuring effects of parathyroid hormone (PTH). Data from 4-5-day metabolic studies in 107 hypercalcaemic patients (78 retrospective and 20 prospective cases) were combined in a hypercalcaemia discrimination index (HDI). HDI = (urine calcium (mg/24 h) x 100 x serum phosphate (mg/100 ml))/(serum total calcium (mg/100 ml)x 24-h clearance of creatinine (ml/min)) expresses in one figure the combined actions of PTH on the renal handling of calcium and on serum phosphate. A multivariate analysis confirmed that HDI offered optimal discrimination. An identical discrimination was observed in the prospective series. In the complete series HDI = 137 was the optimal discrimination point. Classification of the patients as having hyperparathyroidism (HPT) or pseudohyperparathyroidism (P-HPT) (<137) or non-parathyroid hypercalcaemia (NON-PTH) (≥ 137) corresponded in 100 out of 107 patients (93.5%) with the final clinical diagnosis. The effects on HDI of sex, age, season, urine losses, high calcium intake and use of thiazides were also evaluated. HDI appears to be a valuable tool in the endocrine evaluation of hypercalcaemic patients. Used in combination with radioimmunoassays measuring genuine but not ectopic PTH HDI may serve to classify hypercalcaemic patients within the following 3 subgroups: HPT, P-HPT and NON-PTH.
UR - http://www.scopus.com/inward/record.url?scp=0017698579&partnerID=8YFLogxK
U2 - 10.1530/acta.0.0860768
DO - 10.1530/acta.0.0860768
M3 - Journal article
C2 - 579037
AN - SCOPUS:0017698579
VL - 86
SP - 768
EP - 783
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 4
ER -
ID: 202484085