Human papillomavirus related neoplasia of the ocular adnexa
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Human papillomavirus related neoplasia of the ocular adnexa. / Ramberg, Ingvild; Heegaard, Steffen.
In: Viruses, Vol. 13, No. 8, 1522, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Human papillomavirus related neoplasia of the ocular adnexa
AU - Ramberg, Ingvild
AU - Heegaard, Steffen
N1 - Funding Information: This research was funded by the Synoptik Foundation, Denmark; the Danish Eye Research Foundation, Denmark; the Fight for Sight Foundation, Denmark; the Faculty of Health and Medical Sciences, Copenhagen University, Denmark; the Svend Arvid Schr?der and Ketty Lydia Larsen Schr?der Foundation, Denmark; and Copenhagen University Hospital, Rigshospitalet, Denmark. Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.
AB - Human papillomaviruses (HPV) are a large group of DNA viruses that infect the basal cells of the stratified epithelium at different anatomic locations. In the ocular adnexal region, the mucosa of the conjunctiva and the lacrimal drainage system, as well as the eyelid skin, are potential locations for HPV-related neoplasia. The role of HPV in squamous cell neoplasia of the ocular adnexa has been debated for several decades. Due to the rarity of all these tumors, large studies are not available in the scientific literature, thereby hampering the precision of the HPV prevalence estimates and the ability to conclude. Nevertheless, increasing evidence supports that defined subsets of conjunctival papillomas, intraepithelial neoplasia, and carcinomas develop in an HPV-dependent pathway. The role of HPV in squamous cell tumors arising in the lacrimal drainage system and the eyelid is still uncertain. Further, the potential of HPV status as a diagnostic, prognostic, or predictive biomarker in these diseases is a topic for future research.
KW - Conjunctiva
KW - Eyelids
KW - Human papillomavirus
KW - Lacrimal drainage system
KW - Ocular adnexa
KW - Sebaceous cell carcinoma
KW - Squamous cell carcinoma
KW - Squamous cell papilloma
U2 - 10.3390/v13081522
DO - 10.3390/v13081522
M3 - Review
C2 - 34452388
AN - SCOPUS:85112683933
VL - 13
JO - Viruses
JF - Viruses
SN - 1999-4915
IS - 8
M1 - 1522
ER -
ID: 303802098