Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans

Research output: Contribution to journal › Journal article › Research › peer-review

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Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. / Van der Stede, Thibaux; Blancquaert, Laura; Stassen, Flore; Everaert, Inge; Van Thienen, Ruud; Vervaet, Chris; Gliemann, Lasse; Hellsten, Ylva; Derave, Wim.

In: Science Advances, Vol. 7, No. 16, abf2856, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Van der Stede, T, Blancquaert, L, Stassen, F, Everaert, I, Van Thienen, R, Vervaet, C, Gliemann, L, Hellsten, Y & Derave, W 2021, 'Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans', Science Advances, vol. 7, no. 16, abf2856. https://doi.org/10.1126/sciadv.abf2856

APA

Van der Stede, T., Blancquaert, L., Stassen, F., Everaert, I., Van Thienen, R., Vervaet, C., Gliemann, L., Hellsten, Y., & Derave, W. (2021). Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. Science Advances, 7(16), [abf2856]. https://doi.org/10.1126/sciadv.abf2856

Vancouver

Van der Stede T, Blancquaert L, Stassen F, Everaert I, Van Thienen R, Vervaet C et al. Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. Science Advances. 2021;7(16). abf2856. https://doi.org/10.1126/sciadv.abf2856

Author

Van der Stede, Thibaux ; Blancquaert, Laura ; Stassen, Flore ; Everaert, Inge ; Van Thienen, Ruud ; Vervaet, Chris ; Gliemann, Lasse ; Hellsten, Ylva ; Derave, Wim. / Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans. In: Science Advances. 2021 ; Vol. 7, No. 16.

Bibtex

@article{7daa8418c100435b8470a988bea7f401,
title = "Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans",
abstract = "Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training-induced adaptations is not completely understood. We show that chronic blockade of histamine H1/H2 receptors led to marked impairments of microvascular and mitochondrial adaptations to interval training in humans. Consequently, functional adaptations in exercise capacity, whole-body glycemic control, and vascular function were blunted. Furthermore, the sustained elevation of muscle perfusion after acute interval exercise was severely reduced when H1/H2 receptors were pharmaceutically blocked. Our work suggests that histamine H1/H2 receptors are important transducers of the integrative exercise training response in humans, potentially related to regulation of optimal post-exercise muscle perfusion. These findings add to our understanding of how skeletal muscle and the cardiovascular system adapt to exercise training, knowledge that will help us further unravel and develop the exercise-is-medicine concept.",
author = "{Van der Stede}, Thibaux and Laura Blancquaert and Flore Stassen and Inge Everaert and {Van Thienen}, Ruud and Chris Vervaet and Lasse Gliemann and Ylva Hellsten and Wim Derave",
note = "Copyright {\textcopyright} 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).",
year = "2021",
doi = "10.1126/sciadv.abf2856",
language = "English",
volume = "7",
journal = "Science advances",
issn = "2375-2548",
publisher = "American Association for the Advancement of Science",
number = "16",

}

RIS

TY - JOUR

T1 - Histamine H1 and H2 receptors are essential transducers of the integrative exercise training response in humans

AU - Van der Stede, Thibaux

AU - Blancquaert, Laura

AU - Stassen, Flore

AU - Everaert, Inge

AU - Van Thienen, Ruud

AU - Vervaet, Chris

AU - Gliemann, Lasse

AU - Hellsten, Ylva

AU - Derave, Wim

N1 - Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

PY - 2021

Y1 - 2021

N2 - Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training-induced adaptations is not completely understood. We show that chronic blockade of histamine H1/H2 receptors led to marked impairments of microvascular and mitochondrial adaptations to interval training in humans. Consequently, functional adaptations in exercise capacity, whole-body glycemic control, and vascular function were blunted. Furthermore, the sustained elevation of muscle perfusion after acute interval exercise was severely reduced when H1/H2 receptors were pharmaceutically blocked. Our work suggests that histamine H1/H2 receptors are important transducers of the integrative exercise training response in humans, potentially related to regulation of optimal post-exercise muscle perfusion. These findings add to our understanding of how skeletal muscle and the cardiovascular system adapt to exercise training, knowledge that will help us further unravel and develop the exercise-is-medicine concept.

AB - Exercise training is a powerful strategy to prevent and combat cardiovascular and metabolic diseases, although the integrative nature of the training-induced adaptations is not completely understood. We show that chronic blockade of histamine H1/H2 receptors led to marked impairments of microvascular and mitochondrial adaptations to interval training in humans. Consequently, functional adaptations in exercise capacity, whole-body glycemic control, and vascular function were blunted. Furthermore, the sustained elevation of muscle perfusion after acute interval exercise was severely reduced when H1/H2 receptors were pharmaceutically blocked. Our work suggests that histamine H1/H2 receptors are important transducers of the integrative exercise training response in humans, potentially related to regulation of optimal post-exercise muscle perfusion. These findings add to our understanding of how skeletal muscle and the cardiovascular system adapt to exercise training, knowledge that will help us further unravel and develop the exercise-is-medicine concept.

U2 - 10.1126/sciadv.abf2856

DO - 10.1126/sciadv.abf2856

M3 - Journal article

C2 - 33853781

VL - 7

JO - Science advances

JF - Science advances

SN - 2375-2548

IS - 16

M1 - abf2856

ER -

ID: 260200165