Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain.
Research output: Contribution to journal › Journal article › Research › peer-review
The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting increased anaerobic metabolism. Neuronal cell adhesion molecule (NCAM) decreased in pyriform cortex and amygdala of kindled rats, indicating neuronal degeneration.
Original language | English |
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Journal | Brain Research |
Volume | 531 |
Issue number | 1-2 |
Pages (from-to) | 307-11 |
Number of pages | 4 |
ISSN | 0006-8993 |
Publication status | Published - 1990 |
Bibliographical note
Keywords: Animals; Biological Markers; Brain; Cell Adhesion Molecules, Neuronal; Glial Fibrillary Acidic Protein; Hippocampus; Kindling, Neurologic; Male; Nerve Tissue Proteins; Phosphopyruvate Hydratase; Rats; Rats, Inbred Strains; Reference Values; Seizures
ID: 5941339