Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain.
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Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain. / Hansen, A; Jørgensen, Ole Steen; Bolwig, T G; Barry, D I.
In: Brain Research, Vol. 531, No. 1-2, 1990, p. 307-11.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain.
AU - Hansen, A
AU - Jørgensen, Ole Steen
AU - Bolwig, T G
AU - Barry, D I
N1 - Keywords: Animals; Biological Markers; Brain; Cell Adhesion Molecules, Neuronal; Glial Fibrillary Acidic Protein; Hippocampus; Kindling, Neurologic; Male; Nerve Tissue Proteins; Phosphopyruvate Hydratase; Rats; Rats, Inbred Strains; Reference Values; Seizures
PY - 1990
Y1 - 1990
N2 - The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting increased anaerobic metabolism. Neuronal cell adhesion molecule (NCAM) decreased in pyriform cortex and amygdala of kindled rats, indicating neuronal degeneration.
AB - The effect of hippocampal kindling on neuronal and glial marker proteins was studied in the rat by immunochemical methods. In hippocampus, pyriform cortex and amygdala there was an increase in glial fibrillary acidic protein (GFAP), indicating reactive gliosis, and an increase in the glycolytic enzyme NSE, suggesting increased anaerobic metabolism. Neuronal cell adhesion molecule (NCAM) decreased in pyriform cortex and amygdala of kindled rats, indicating neuronal degeneration.
M3 - Journal article
C2 - 2289130
VL - 531
SP - 307
EP - 311
JO - Brain Research
JF - Brain Research
SN - 0006-8993
IS - 1-2
ER -
ID: 5941339