High tumor uptake of (64)Cu: implications for molecular imaging of tumor characteristics with copper-based PET tracers
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High tumor uptake of (64)Cu : implications for molecular imaging of tumor characteristics with copper-based PET tracers. / Jørgensen, Jesper Tranekjær; Persson, Morten; Madsen, Jacob; Kjær, Andreas.
In: Nuclear Medicine and Biology, Vol. 40, No. 3, 04.2013, p. 345-50.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - High tumor uptake of (64)Cu
T2 - implications for molecular imaging of tumor characteristics with copper-based PET tracers
AU - Jørgensen, Jesper Tranekjær
AU - Persson, Morten
AU - Madsen, Jacob
AU - Kjær, Andreas
N1 - Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2013/4
Y1 - 2013/4
N2 - The use of copper-based positron emission tomography (PET) tracers in cancer studies is increasing. However, as copper has previously been found in high concentrations in human tumor tissue in vivo, instability of PET tracers could result in tumor accumulation of non-tracer-bound radioactive copper that may influence PET measurements. Here we determine the degree of (64)Cu uptake in five commonly used human cancer xenograft models in mice. Additionally, we compare copper accumulation in tumor tissue to gene expression of human copper transporter 1 (CTR1).
AB - The use of copper-based positron emission tomography (PET) tracers in cancer studies is increasing. However, as copper has previously been found in high concentrations in human tumor tissue in vivo, instability of PET tracers could result in tumor accumulation of non-tracer-bound radioactive copper that may influence PET measurements. Here we determine the degree of (64)Cu uptake in five commonly used human cancer xenograft models in mice. Additionally, we compare copper accumulation in tumor tissue to gene expression of human copper transporter 1 (CTR1).
U2 - 10.1016/j.nucmedbio.2013.01.002
DO - 10.1016/j.nucmedbio.2013.01.002
M3 - Journal article
C2 - 23394821
VL - 40
SP - 345
EP - 350
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
SN - 0969-8051
IS - 3
ER -
ID: 45845300