Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
Research output: Contribution to journal › Journal article › Research
Standard
Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice. / Christoffersen, Christina; Bartels, E D; Nielsen, L B.
In: European Journal of Clinical Investigation, Vol. 36, No. 2, 02.2006, p. 69-75.Research output: Contribution to journal › Journal article › Research
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Heart specific up-regulation of genes for B-type and C-type natriuretic peptide receptors in diabetic mice
AU - Christoffersen, Christina
AU - Bartels, E D
AU - Nielsen, L B
PY - 2006/2
Y1 - 2006/2
N2 - Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.
AB - Diabetes may cause cardiomyopathy characterized by cardiac fibrosis. Recent studies of genetically modified mice have elucidated a role of the natriuretic peptides (NP), type-A and type-B (ANP and BNP), and their common receptor [natriuretic peptide receptor (NPR), type-A] in development of cardiac fibrosis. The role of NP type-C (CNP) and NPR type-B (NPR-B) in the heart is less well established. In this study we examined if diabetes alters heart expression of the genes encoding the NP and its receptors.
KW - Animals
KW - Atrial Natriuretic Factor
KW - Diabetes Mellitus, Experimental
KW - Diabetes Mellitus, Type 1
KW - Guanylate Cyclase
KW - Heart
KW - Male
KW - Mice
KW - Mice, Inbred C57BL
KW - Natriuretic Peptide, Brain
KW - Natriuretic Peptide, C-Type
KW - Natriuretic Peptides
KW - RNA, Messenger
KW - Receptors, Atrial Natriuretic Factor
KW - Up-Regulation
U2 - 10.1111/j.1365-2362.2006.01596.x
DO - 10.1111/j.1365-2362.2006.01596.x
M3 - Journal article
C2 - 16436087
VL - 36
SP - 69
EP - 75
JO - Zeitschrift fur klinische Medizin
JF - Zeitschrift fur klinische Medizin
SN - 0014-2972
IS - 2
ER -
ID: 100888776