HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births: A Case Report
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HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births : A Case Report. / Liest, Sara; Riishede Christiansen, Iben; Prætorius, Lisbeth; Bogstad, Jeanette; Freiesleben, Nina la Cour; Pinborg, Anja; Løssl, Kristine.
In: Frontiers in Reproductive Health, Vol. 3, 764299, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - HCG Trigger After Failed GnRH Agonist Trigger Resulted in Two Consecutive Live Births
T2 - A Case Report
AU - Liest, Sara
AU - Riishede Christiansen, Iben
AU - Prætorius, Lisbeth
AU - Bogstad, Jeanette
AU - Freiesleben, Nina la Cour
AU - Pinborg, Anja
AU - Løssl, Kristine
PY - 2021
Y1 - 2021
N2 - Background: Failed gonadotropin-releasing hormone (GnRH) agonist trigger with no oocyte retrieved during aspiration of several follicles is a rare but recurrent situation that can be rescued by the termination of the aspiration procedure, retriggering by human chorion gonadotropin (hCG), and repeated oocyte pickup 36 h later. Failed GnRH agonist trigger is frustrating and unsatisfactory, and fertility doctors must be aware of possible hCG retriggering and retained opportunity for successful cycle outcome. Objective: In this case report, we present a woman who experienced failed GnRH agonist trigger and rescue hCG retrigger followed by two consecutive live births after frozen-thawed single blastocyst transfers. Methods: A case report. Results: Two healthy children were born in 2018 and 2020, respectively as a result of controlled ovarian stimulation for IVF, failed GnRH agonist trigger followed by hCG re-trigger, and successful retrieval of 25 oocytes. Conclusion: Retriggering with hCG after failed GnRH agonist trigger can result in consecutive live births, and such knowledge can prevent cycle cancellation and patient discouragement. Knowledge on retriggering with hCG and consecutive live births after failed GnRH agonist trigger can prevent cycle cancellation and patient discouragement.
AB - Background: Failed gonadotropin-releasing hormone (GnRH) agonist trigger with no oocyte retrieved during aspiration of several follicles is a rare but recurrent situation that can be rescued by the termination of the aspiration procedure, retriggering by human chorion gonadotropin (hCG), and repeated oocyte pickup 36 h later. Failed GnRH agonist trigger is frustrating and unsatisfactory, and fertility doctors must be aware of possible hCG retriggering and retained opportunity for successful cycle outcome. Objective: In this case report, we present a woman who experienced failed GnRH agonist trigger and rescue hCG retrigger followed by two consecutive live births after frozen-thawed single blastocyst transfers. Methods: A case report. Results: Two healthy children were born in 2018 and 2020, respectively as a result of controlled ovarian stimulation for IVF, failed GnRH agonist trigger followed by hCG re-trigger, and successful retrieval of 25 oocytes. Conclusion: Retriggering with hCG after failed GnRH agonist trigger can result in consecutive live births, and such knowledge can prevent cycle cancellation and patient discouragement. Knowledge on retriggering with hCG and consecutive live births after failed GnRH agonist trigger can prevent cycle cancellation and patient discouragement.
U2 - 10.3389/frph.2021.764299
DO - 10.3389/frph.2021.764299
M3 - Journal article
C2 - 36303957
VL - 3
JO - Frontiers in Reproductive Health
JF - Frontiers in Reproductive Health
M1 - 764299
ER -
ID: 301345987