Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning
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Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning. / Thymann, Thomas; Le Huërou-Luron, I; Petersen, Y M; Hedemann, Mette Skou; Elinf, J; Jensen, B B; Holst, Jens Juul; Hartmann, Bolette; Sangild, Per Torp.
In: Journal of Animal Science, Vol. 92, No. 5, 2014, p. 2070-2079.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Glucagon-like peptide 2 treatment may improve intestinal adaptation during weaning
AU - Thymann, Thomas
AU - Le Huërou-Luron, I
AU - Petersen, Y M
AU - Hedemann, Mette Skou
AU - Elinf, J
AU - Jensen, B B
AU - Holst, Jens Juul
AU - Hartmann, Bolette
AU - Sangild, Per Torp
N1 - CURIS 2014 NEXS 128
PY - 2014
Y1 - 2014
N2 - Transition from sow's milk to solid feed is associated with intestinal atrophy and diarrhea. We hypothesized that the intestinotrophic hormone glucagon-like peptide 2 (GLP-2) would induce a dose- and health status-dependent effect on gut adaptation. In Exp. 1, weaned pigs (average BW at weaning 4.98 ± 0.18 kg) were kept in a high-sanitary environment and injected with saline or short-acting GLP-2 (80 μg/(kg BW·12 h); n = 8). Under these conditions, there was no diarrhea and GLP-2 did not improve gastrointestinal structure or function. In Exp. 2, weaned pigs (average BW at weaning 6.68 ± 0.27 kg) were kept in a low-sanitary environment, leading to weaning diarrhea, and injected with saline or short-acting GLP-2 (200 µg/(kg BW·12 h); n = 11). Treatment with GLP-2 increased goblet cell density (P 20,000 pmol/L) and Exp. 2 (increases to 20,000 pmol/L for a few hours each day) while they were in the supraphysiological range in Exp. 1 (50-200 pmol/L). In conclusion, GLP-2 may improve gut structure and function in weanling pigs. However, the effects may be significant only under conditions of diarrhea and if GLP-2 exposure time is extended using long-acting analogues.
AB - Transition from sow's milk to solid feed is associated with intestinal atrophy and diarrhea. We hypothesized that the intestinotrophic hormone glucagon-like peptide 2 (GLP-2) would induce a dose- and health status-dependent effect on gut adaptation. In Exp. 1, weaned pigs (average BW at weaning 4.98 ± 0.18 kg) were kept in a high-sanitary environment and injected with saline or short-acting GLP-2 (80 μg/(kg BW·12 h); n = 8). Under these conditions, there was no diarrhea and GLP-2 did not improve gastrointestinal structure or function. In Exp. 2, weaned pigs (average BW at weaning 6.68 ± 0.27 kg) were kept in a low-sanitary environment, leading to weaning diarrhea, and injected with saline or short-acting GLP-2 (200 µg/(kg BW·12 h); n = 11). Treatment with GLP-2 increased goblet cell density (P 20,000 pmol/L) and Exp. 2 (increases to 20,000 pmol/L for a few hours each day) while they were in the supraphysiological range in Exp. 1 (50-200 pmol/L). In conclusion, GLP-2 may improve gut structure and function in weanling pigs. However, the effects may be significant only under conditions of diarrhea and if GLP-2 exposure time is extended using long-acting analogues.
U2 - 10.2527/jas.2013-7015
DO - 10.2527/jas.2013-7015
M3 - Journal article
C2 - 24663206
VL - 92
SP - 2070
EP - 2079
JO - Journal of Animal Science
JF - Journal of Animal Science
SN - 0021-8812
IS - 5
ER -
ID: 109556497