Glomerular matrix: synthesis, turnover and role in mesangial expansion.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Glomerular matrix: synthesis, turnover and role in mesangial expansion. / Couchman, J R; Beavan, L A; McCarthy, K J.

In: Kidney International, Vol. 45, No. 2, 1994, p. 328-35.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Couchman, JR, Beavan, LA & McCarthy, KJ 1994, 'Glomerular matrix: synthesis, turnover and role in mesangial expansion.', Kidney International, vol. 45, no. 2, pp. 328-35.

APA

Couchman, J. R., Beavan, L. A., & McCarthy, K. J. (1994). Glomerular matrix: synthesis, turnover and role in mesangial expansion. Kidney International, 45(2), 328-35.

Vancouver

Couchman JR, Beavan LA, McCarthy KJ. Glomerular matrix: synthesis, turnover and role in mesangial expansion. Kidney International. 1994;45(2):328-35.

Author

Couchman, J R ; Beavan, L A ; McCarthy, K J. / Glomerular matrix: synthesis, turnover and role in mesangial expansion. In: Kidney International. 1994 ; Vol. 45, No. 2. pp. 328-35.

Bibtex

@article{7e16c800597911dd8d9f000ea68e967b,
title = "Glomerular matrix: synthesis, turnover and role in mesangial expansion.",
abstract = "The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.",
author = "Couchman, {J R} and Beavan, {L A} and McCarthy, {K J}",
note = "Keywords: Diabetes Mellitus; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Glomerular Mesangium; Humans; Kidney Glomerulus; Proteoglycans; Signal Transduction",
year = "1994",
language = "English",
volume = "45",
pages = "328--35",
journal = "Kidney International",
issn = "0085-2538",
publisher = "Elsevier",
number = "2",

}

RIS

TY - JOUR

T1 - Glomerular matrix: synthesis, turnover and role in mesangial expansion.

AU - Couchman, J R

AU - Beavan, L A

AU - McCarthy, K J

N1 - Keywords: Diabetes Mellitus; Extracellular Matrix; Extracellular Matrix Proteins; Fibronectins; Glomerular Mesangium; Humans; Kidney Glomerulus; Proteoglycans; Signal Transduction

PY - 1994

Y1 - 1994

N2 - The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.

AB - The extracellular matrix has an integral role in development, homeostasis and pathology of the glomerulus. Three spatially distinct matrices are present in the glomerulus: the mesangium, and basement membranes of the capillary loops and Bowman's capsule. Each is dominated by basement membrane components, but is distinct in organization and composition. Many matrix components influence cell behavior directly, through specific interactions with receptors, or indirectly through growth factor sequestration. Growth factors may be of great importance in development and disease progression in the glomerulus, and may be central to mesangial expansion. In addition, changes in matrix composition accompany and contribute to the pathological condition, such as the accumulation of matrix in diabetes mellitus.

M3 - Journal article

C2 - 8164416

VL - 45

SP - 328

EP - 335

JO - Kidney International

JF - Kidney International

SN - 0085-2538

IS - 2

ER -

ID: 5165657