Standard
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. / Justice, Anne E; Winkler, Thomas W; Feitosa, Mary F; Graff, Misa; Fisher, Virginia A; Young, Kristin L; Barata, Llilda; Deng, Xuan; Czajkowski, Jacek; Hadley, David; Ngwa, Julius S; Ahluwalia, Tarunveer Singh; Chu, Audrey Y; Heard-Costa, Nancy L; Lim, Elise; Perez, Jeremiah; Eicher, John D; Kutalik, Zoltan; Xue, Luting; Mahajan, Anubha; Renström, Frida; Wu, Joseph C; Qi, Qibin; Ahmad, Shafqat; Alfred, Tamuno; Amin, Najaf; Bielak, Lawrence F; Bonnefond, Amélie; Bragg-Gresham, Jennifer L; Cadby, Gemma; Chittani, Martina; Coggeshall, Scott; Corre, Tanguy; Direk, Nese; Eriksson, Joel; Fischer, Krista; Gorski, Mathias; Neergaard Harder, Marie; Horikoshi, Momoko; Huang, Tao-wei; Huffman, Jennifer E; Jackson, Anne U; Justesen, Johanne Marie; Kanoni, Stavroula; Kinnunen, Leena; Kleber, Marcus E; Komulainen, Pirjo; Kumari, Meena; Lim, Unhee; Luan, Jian'an; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Manichaikul, Ani; Marten, Jonathan; Middelberg, Rita P S; Müller-Nurasyid, Martina; Navarro, Pau; Pérusse, Louis; Pervjakova, Natalia; Sarti, Cinzia; Smith, Albert Vernon; Smith, Jennifer A; Stančáková, Alena; Strawbridge, Rona J; Stringham, Heather M; Sung, Yun Ju; Tanaka, Toshiko; Teumer, Alexander; Trompet, Stella; van der Laan, Sander W; van der Most, Peter J; van Vliet-Ostaptchouk, Jana V; Vedantam, Sailaja L; Verweij, Niek; Vink, Jacqueline M; Vitart, Veronique; Wu, Ying; Yengo, Loic; Zhang, Weihua; Hua Zhao, Jing; Zimmermann, Martina E; Zubair, Niha; Abecasis, Goncalo R; Adair, Linda S; Afaq, Saima; Afzal, Uzma; Bakker, Stephan J L; Bartz, Traci M; Beilby, John; Bergman, Richard N; Bergmann, Sven; Biffar, Reiner; Blangero, John; Boerwinkle, Eric; Bonnycastle, Lori L; Bottinger, Erwin P; Braga, Daniele; Buckley, Brendan M; Buyske, Steve; Campbell, Harry; Chambers, John C; Collins, Francis S; Curran, Joanne E; de Borst, Gert Jan; De Craen, Anton J M; de Geus, Eco J C; Dedoussis, George; Delgado, Graciela E; den Ruijter, Hester M; Eiriksdottir, Gudny; Eriksson, Anna L; Esko, Tõnu; Faul, Jessica D; Ford, Ian; Forrester, Terrence; Gertow, Karl; Gigante, Bruna; Glorioso, Nicola; Gong, Jian; Grallert, Harald; Grammer, Tanja B; Grarup, Niels; Haitjema, Saskia; Hallmans, Göran; Hamsten, Anders; Hansen, Torben; Harris, Tamara B; Hartman, Catharina A; Hassinen, Maija; Hastie, Nicholas D; Heath, Andrew C; Hernandez, Dena; Hindorff, Lucia A; Hocking, Lynne J; Hollensted, Mette; Holmen, Oddgeir L; Homuth, Georg; Jan Hottenga, Jouke; Huang, Jie; Hung, Joseph; Hutri-Kähönen, Nina; Ingelsson, Erik; James, Alan L; Jansson, John-Olov; Jarvelin, Marjo Riitta; Jhun, Min A; Jørgensen, Marit E; Juonala, Markus; Kähönen, Mika; Karlsson, Magnus; Koistinen, Heikki A; Kolcic, Ivana; Kolovou, Genovefa; Kooperberg, Charles; Krämer, Bernhard K; Kuusisto, Johanna; Kvaløy, Kirsti; Lakka, Timo A; Langenberg, Claudia; Launer, Lenore J; Leander, Karin; Lee, Nanette R; Lind, Lars; Lindgren, Cecilia M; Linneberg, Allan; Lobbens, Stéphane; Loh, Marie; Lorentzon, Mattias; Luben, Robert; Lubke, Gitta; Ludolph-Donislawski, Anja; Lupoli, Sara; Madden, Pamela A F; Männikkö, Reija; Marques-Vidal, Pedro; Martin, Nicholas G.; Mckenzie, Colin A; McKnight, Barbara; Mellström, Dan; Menni, Cristina; Montgomery, Grant W.; Musk, Aw Bill; Narisu, Narisu; Nauck, Matthias; Nolte, Ilja M; Oldehinkel, Albertine J; Olden, Matthias; Ong, Ken K; Padmanabhan, Sandosh; Peyser, Patricia A; Pisinger, Charlotta; Porteous, David J; Raitakari, Olli T; Rankinen, Tuomo; Rao, Dabeeru C; Rasmussen-Torvik, Laura J; Rawal, Rajesh; Rice, Treva K; Ridker, Paul M; Rose, Lynda M; Bien, Stephanie A; Rudan, Igor; Sanna, Serena; Sarzynski, Mark A; Sattar, Naveed; Savonen, Kai; Schlessinger, David; Scholtens, Salome; Schurmann, Claudia; Scott, Robert A; Sennblad, Bengt; Siemelink, Marten A; Silbernagel, Günther; Slagboom, P Eline; Snieder, Harold; Staessen, Jan A.; Stott, David J; Swertz, Morris A; Swift, Amy J; Taylor, Kent D; Tayo, Bamidele O; Thorand, Barbara; Thuillier, Dorothee; Tuomilehto, Jaakko; Uitterlinden, Andre G; Vandenput, Liesbeth; Vohl, Marie-Claude; Völzke, Henry; Vonk, Judith M; Waeber, Gerard; Waldenberger, Melanie; Westendorp, R G J; Wild, Sarah; Willemsen, Gonneke; Wolffenbuttel, Bruce H R; Wong, Andrew; Wright, Alan F; Zhao, Wei; Zillikens, M Carola; Baldassarre, Damiano; Balkau, Beverley; Bandinelli, Stefania; Böger, Carsten A; Boomsma, Dorret I; Bouchard, Claude; Bruinenberg, Marcel; Chasman, Daniel I; Chen, Yii-DerIda; Chines, Peter S; Cooper, Richard S; Cucca, Francesco; Cusi, Daniele; Faire, Ulf de; Ferrucci, Luigi; Franks, Paul W; Froguel, Philippe; Gordon-Larsen, Penny; Grabe, Hans Jörgen; Gudnason, Vilmundur; Haiman, Christopher A; Hayward, Caroline; Hveem, Kristian; Johnson, Andrew D; Wouter Jukema, J; Kardia, Sharon L R; Kivimaki, Mika; Kooner, Jaspal S; Kuh, Diana; Laakso, Markku; Lehtimäki, Terho; Marchand, Loic Le; März, Winfried; McCarthy, Mark I; Metspalu, Andres; Morris, Andrew P; Ohlsson, Claes; Palmer, Lyle J; Pasterkamp, Gerard; Pedersen, Oluf; Peters, Annette; Peters, Ulrike; Polasek, Ozren; Psaty, Bruce M; Qi, Lu; Rauramaa, Rainer; Smith, Blair H; Sørensen, Thorkild I A; Strauch, Konstantin; Tiemeier, Henning; Tremoli, Elena; van der Harst, Pim; Vestergaard, Henrik; Vollenweider, Peter; Wareham, Nicholas J; Weir, David R; Whitfield, John B; Wilson, James F; Tyrrell, Jessica; Frayling, Timothy M; Barroso, Inês; Boehnke, Michael; Deloukas, Panagiotis; Fox, Caroline S; Hirschhorn, Joel N; Hunter, David J; Spector, Tim D; Strachan, David P; van Duijn, Cornélia M; Heid, Iris M; Mohlke, Karen L; Marchini, Jonathan L; Loos, Ruth J F; Kilpeläinen, Tuomas O; Liu, Ching-Ti; Borecki, Ingrid B; North, Kari E; Cupples, L Adrienne.
In:
Nature Communications, Vol. 8, 14977, 26.04.2017.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Justice, AE, Winkler, TW, Feitosa, MF, Graff, M, Fisher, VA, Young, KL, Barata, L, Deng, X, Czajkowski, J, Hadley, D, Ngwa, JS
, Ahluwalia, TS, Chu, AY, Heard-Costa, NL, Lim, E, Perez, J, Eicher, JD, Kutalik, Z, Xue, L, Mahajan, A, Renström, F, Wu, JC, Qi, Q, Ahmad, S, Alfred, T, Amin, N, Bielak, LF, Bonnefond, A, Bragg-Gresham, JL, Cadby, G, Chittani, M, Coggeshall, S, Corre, T, Direk, N, Eriksson, J, Fischer, K, Gorski, M, Neergaard Harder, M, Horikoshi, M, Huang, T, Huffman, JE, Jackson, AU
, Justesen, JM, Kanoni, S, Kinnunen, L, Kleber, ME, Komulainen, P, Kumari, M, Lim, U, Luan, J, Lyytikäinen, L-P, Mangino, M, Manichaikul, A, Marten, J, Middelberg, RPS, Müller-Nurasyid, M, Navarro, P, Pérusse, L, Pervjakova, N, Sarti, C, Smith, AV, Smith, JA, Stančáková, A, Strawbridge, RJ, Stringham, HM, Sung, YJ, Tanaka, T, Teumer, A, Trompet, S, van der Laan, SW, van der Most, PJ, van Vliet-Ostaptchouk, JV, Vedantam, SL, Verweij, N, Vink, JM, Vitart, V, Wu, Y, Yengo, L, Zhang, W, Hua Zhao, J, Zimmermann, ME, Zubair, N, Abecasis, GR, Adair, LS, Afaq, S, Afzal, U, Bakker, SJL, Bartz, TM, Beilby, J, Bergman, RN, Bergmann, S, Biffar, R, Blangero, J, Boerwinkle, E, Bonnycastle, LL, Bottinger, EP, Braga, D, Buckley, BM, Buyske, S, Campbell, H, Chambers, JC, Collins, FS, Curran, JE, de Borst, GJ, De Craen, AJM, de Geus, EJC, Dedoussis, G, Delgado, GE, den Ruijter, HM, Eiriksdottir, G, Eriksson, AL, Esko, T, Faul, JD, Ford, I, Forrester, T, Gertow, K, Gigante, B, Glorioso, N, Gong, J, Grallert, H, Grammer, TB, Grarup, N, Haitjema, S, Hallmans, G, Hamsten, A
, Hansen, T, Harris, TB, Hartman, CA, Hassinen, M, Hastie, ND, Heath, AC, Hernandez, D, Hindorff, LA, Hocking, LJ, Hollensted, M, Holmen, OL, Homuth, G, Jan Hottenga, J, Huang, J, Hung, J, Hutri-Kähönen, N, Ingelsson, E, James, AL, Jansson, J-O, Jarvelin, MR, Jhun, MA, Jørgensen, ME, Juonala, M, Kähönen, M, Karlsson, M, Koistinen, HA, Kolcic, I, Kolovou, G, Kooperberg, C, Krämer, BK, Kuusisto, J, Kvaløy, K, Lakka, TA, Langenberg, C, Launer, LJ, Leander, K, Lee, NR, Lind, L, Lindgren, CM
, Linneberg, A, Lobbens, S, Loh, M, Lorentzon, M, Luben, R, Lubke, G, Ludolph-Donislawski, A, Lupoli, S, Madden, PAF, Männikkö, R, Marques-Vidal, P, Martin, NG, Mckenzie, CA, McKnight, B, Mellström, D, Menni, C, Montgomery, GW, Musk, AB, Narisu, N, Nauck, M, Nolte, IM, Oldehinkel, AJ, Olden, M, Ong, KK, Padmanabhan, S, Peyser, PA, Pisinger, C, Porteous, DJ, Raitakari, OT, Rankinen, T, Rao, DC, Rasmussen-Torvik, LJ, Rawal, R, Rice, TK, Ridker, PM, Rose, LM, Bien, SA, Rudan, I, Sanna, S, Sarzynski, MA, Sattar, N, Savonen, K, Schlessinger, D, Scholtens, S, Schurmann, C, Scott, RA, Sennblad, B, Siemelink, MA, Silbernagel, G, Slagboom, PE, Snieder, H, Staessen, JA, Stott, DJ, Swertz, MA, Swift, AJ, Taylor, KD, Tayo, BO, Thorand, B, Thuillier, D, Tuomilehto, J, Uitterlinden, AG, Vandenput, L, Vohl, M-C, Völzke, H, Vonk, JM, Waeber, G, Waldenberger, M, Westendorp, RGJ, Wild, S, Willemsen, G, Wolffenbuttel, BHR, Wong, A, Wright, AF, Zhao, W, Zillikens, MC, Baldassarre, D, Balkau, B, Bandinelli, S, Böger, CA, Boomsma, DI, Bouchard, C, Bruinenberg, M, Chasman, DI, Chen, Y-D, Chines, PS, Cooper, RS, Cucca, F, Cusi, D, Faire, UD, Ferrucci, L, Franks, PW, Froguel, P, Gordon-Larsen, P, Grabe, HJ, Gudnason, V, Haiman, CA, Hayward, C, Hveem, K, Johnson, AD, Wouter Jukema, J, Kardia, SLR, Kivimaki, M, Kooner, JS, Kuh, D, Laakso, M, Lehtimäki, T, Marchand, LL, März, W, McCarthy, MI, Metspalu, A, Morris, AP, Ohlsson, C, Palmer, LJ, Pasterkamp, G
, Pedersen, O, Peters, A, Peters, U, Polasek, O, Psaty, BM, Qi, L, Rauramaa, R, Smith, BH
, Sørensen, TIA, Strauch, K, Tiemeier, H, Tremoli, E, van der Harst, P
, Vestergaard, H, Vollenweider, P, Wareham, NJ, Weir, DR, Whitfield, JB, Wilson, JF, Tyrrell, J, Frayling, TM, Barroso, I, Boehnke, M, Deloukas, P, Fox, CS, Hirschhorn, JN, Hunter, DJ, Spector, TD, Strachan, DP, van Duijn, CM, Heid, IM, Mohlke, KL, Marchini, JL, Loos, RJF
, Kilpeläinen, TO, Liu, C-T, Borecki, IB, North, KE & Cupples, LA 2017, '
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits',
Nature Communications, vol. 8, 14977.
https://doi.org/10.1038/ncomms14977
APA
Justice, A. E., Winkler, T. W., Feitosa, M. F., Graff, M., Fisher, V. A., Young, K. L., Barata, L., Deng, X., Czajkowski, J., Hadley, D., Ngwa, J. S.
, Ahluwalia, T. S., Chu, A. Y., Heard-Costa, N. L., Lim, E., Perez, J., Eicher, J. D., Kutalik, Z., Xue, L., ... Cupples, L. A. (2017).
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Nature Communications,
8, [14977].
https://doi.org/10.1038/ncomms14977
Vancouver
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young KL et al.
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits.
Nature Communications. 2017 Apr 26;8. 14977.
https://doi.org/10.1038/ncomms14977
Author
Justice, Anne E ; Winkler, Thomas W ; Feitosa, Mary F ; Graff, Misa ; Fisher, Virginia A ; Young, Kristin L ; Barata, Llilda ; Deng, Xuan ; Czajkowski, Jacek ; Hadley, David ; Ngwa, Julius S ; Ahluwalia, Tarunveer Singh ; Chu, Audrey Y ; Heard-Costa, Nancy L ; Lim, Elise ; Perez, Jeremiah ; Eicher, John D ; Kutalik, Zoltan ; Xue, Luting ; Mahajan, Anubha ; Renström, Frida ; Wu, Joseph C ; Qi, Qibin ; Ahmad, Shafqat ; Alfred, Tamuno ; Amin, Najaf ; Bielak, Lawrence F ; Bonnefond, Amélie ; Bragg-Gresham, Jennifer L ; Cadby, Gemma ; Chittani, Martina ; Coggeshall, Scott ; Corre, Tanguy ; Direk, Nese ; Eriksson, Joel ; Fischer, Krista ; Gorski, Mathias ; Neergaard Harder, Marie ; Horikoshi, Momoko ; Huang, Tao-wei ; Huffman, Jennifer E ; Jackson, Anne U ; Justesen, Johanne Marie ; Kanoni, Stavroula ; Kinnunen, Leena ; Kleber, Marcus E ; Komulainen, Pirjo ; Kumari, Meena ; Lim, Unhee ; Luan, Jian'an ; Lyytikäinen, Leo-Pekka ; Mangino, Massimo ; Manichaikul, Ani ; Marten, Jonathan ; Middelberg, Rita P S ; Müller-Nurasyid, Martina ; Navarro, Pau ; Pérusse, Louis ; Pervjakova, Natalia ; Sarti, Cinzia ; Smith, Albert Vernon ; Smith, Jennifer A ; Stančáková, Alena ; Strawbridge, Rona J ; Stringham, Heather M ; Sung, Yun Ju ; Tanaka, Toshiko ; Teumer, Alexander ; Trompet, Stella ; van der Laan, Sander W ; van der Most, Peter J ; van Vliet-Ostaptchouk, Jana V ; Vedantam, Sailaja L ; Verweij, Niek ; Vink, Jacqueline M ; Vitart, Veronique ; Wu, Ying ; Yengo, Loic ; Zhang, Weihua ; Hua Zhao, Jing ; Zimmermann, Martina E ; Zubair, Niha ; Abecasis, Goncalo R ; Adair, Linda S ; Afaq, Saima ; Afzal, Uzma ; Bakker, Stephan J L ; Bartz, Traci M ; Beilby, John ; Bergman, Richard N ; Bergmann, Sven ; Biffar, Reiner ; Blangero, John ; Boerwinkle, Eric ; Bonnycastle, Lori L ; Bottinger, Erwin P ; Braga, Daniele ; Buckley, Brendan M ; Buyske, Steve ; Campbell, Harry ; Chambers, John C ; Collins, Francis S ; Curran, Joanne E ; de Borst, Gert Jan ; De Craen, Anton J M ; de Geus, Eco J C ; Dedoussis, George ; Delgado, Graciela E ; den Ruijter, Hester M ; Eiriksdottir, Gudny ; Eriksson, Anna L ; Esko, Tõnu ; Faul, Jessica D ; Ford, Ian ; Forrester, Terrence ; Gertow, Karl ; Gigante, Bruna ; Glorioso, Nicola ; Gong, Jian ; Grallert, Harald ; Grammer, Tanja B ; Grarup, Niels ; Haitjema, Saskia ; Hallmans, Göran ; Hamsten, Anders ; Hansen, Torben ; Harris, Tamara B ; Hartman, Catharina A ; Hassinen, Maija ; Hastie, Nicholas D ; Heath, Andrew C ; Hernandez, Dena ; Hindorff, Lucia A ; Hocking, Lynne J ; Hollensted, Mette ; Holmen, Oddgeir L ; Homuth, Georg ; Jan Hottenga, Jouke ; Huang, Jie ; Hung, Joseph ; Hutri-Kähönen, Nina ; Ingelsson, Erik ; James, Alan L ; Jansson, John-Olov ; Jarvelin, Marjo Riitta ; Jhun, Min A ; Jørgensen, Marit E ; Juonala, Markus ; Kähönen, Mika ; Karlsson, Magnus ; Koistinen, Heikki A ; Kolcic, Ivana ; Kolovou, Genovefa ; Kooperberg, Charles ; Krämer, Bernhard K ; Kuusisto, Johanna ; Kvaløy, Kirsti ; Lakka, Timo A ; Langenberg, Claudia ; Launer, Lenore J ; Leander, Karin ; Lee, Nanette R ; Lind, Lars ; Lindgren, Cecilia M ; Linneberg, Allan ; Lobbens, Stéphane ; Loh, Marie ; Lorentzon, Mattias ; Luben, Robert ; Lubke, Gitta ; Ludolph-Donislawski, Anja ; Lupoli, Sara ; Madden, Pamela A F ; Männikkö, Reija ; Marques-Vidal, Pedro ; Martin, Nicholas G. ; Mckenzie, Colin A ; McKnight, Barbara ; Mellström, Dan ; Menni, Cristina ; Montgomery, Grant W. ; Musk, Aw Bill ; Narisu, Narisu ; Nauck, Matthias ; Nolte, Ilja M ; Oldehinkel, Albertine J ; Olden, Matthias ; Ong, Ken K ; Padmanabhan, Sandosh ; Peyser, Patricia A ; Pisinger, Charlotta ; Porteous, David J ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, Dabeeru C ; Rasmussen-Torvik, Laura J ; Rawal, Rajesh ; Rice, Treva K ; Ridker, Paul M ; Rose, Lynda M ; Bien, Stephanie A ; Rudan, Igor ; Sanna, Serena ; Sarzynski, Mark A ; Sattar, Naveed ; Savonen, Kai ; Schlessinger, David ; Scholtens, Salome ; Schurmann, Claudia ; Scott, Robert A ; Sennblad, Bengt ; Siemelink, Marten A ; Silbernagel, Günther ; Slagboom, P Eline ; Snieder, Harold ; Staessen, Jan A. ; Stott, David J ; Swertz, Morris A ; Swift, Amy J ; Taylor, Kent D ; Tayo, Bamidele O ; Thorand, Barbara ; Thuillier, Dorothee ; Tuomilehto, Jaakko ; Uitterlinden, Andre G ; Vandenput, Liesbeth ; Vohl, Marie-Claude ; Völzke, Henry ; Vonk, Judith M ; Waeber, Gerard ; Waldenberger, Melanie ; Westendorp, R G J ; Wild, Sarah ; Willemsen, Gonneke ; Wolffenbuttel, Bruce H R ; Wong, Andrew ; Wright, Alan F ; Zhao, Wei ; Zillikens, M Carola ; Baldassarre, Damiano ; Balkau, Beverley ; Bandinelli, Stefania ; Böger, Carsten A ; Boomsma, Dorret I ; Bouchard, Claude ; Bruinenberg, Marcel ; Chasman, Daniel I ; Chen, Yii-DerIda ; Chines, Peter S ; Cooper, Richard S ; Cucca, Francesco ; Cusi, Daniele ; Faire, Ulf de ; Ferrucci, Luigi ; Franks, Paul W ; Froguel, Philippe ; Gordon-Larsen, Penny ; Grabe, Hans Jörgen ; Gudnason, Vilmundur ; Haiman, Christopher A ; Hayward, Caroline ; Hveem, Kristian ; Johnson, Andrew D ; Wouter Jukema, J ; Kardia, Sharon L R ; Kivimaki, Mika ; Kooner, Jaspal S ; Kuh, Diana ; Laakso, Markku ; Lehtimäki, Terho ; Marchand, Loic Le ; März, Winfried ; McCarthy, Mark I ; Metspalu, Andres ; Morris, Andrew P ; Ohlsson, Claes ; Palmer, Lyle J ; Pasterkamp, Gerard ; Pedersen, Oluf ; Peters, Annette ; Peters, Ulrike ; Polasek, Ozren ; Psaty, Bruce M ; Qi, Lu ; Rauramaa, Rainer ; Smith, Blair H ; Sørensen, Thorkild I A ; Strauch, Konstantin ; Tiemeier, Henning ; Tremoli, Elena ; van der Harst, Pim ; Vestergaard, Henrik ; Vollenweider, Peter ; Wareham, Nicholas J ; Weir, David R ; Whitfield, John B ; Wilson, James F ; Tyrrell, Jessica ; Frayling, Timothy M ; Barroso, Inês ; Boehnke, Michael ; Deloukas, Panagiotis ; Fox, Caroline S ; Hirschhorn, Joel N ; Hunter, David J ; Spector, Tim D ; Strachan, David P ; van Duijn, Cornélia M ; Heid, Iris M ; Mohlke, Karen L ; Marchini, Jonathan L ; Loos, Ruth J F ; Kilpeläinen, Tuomas O ; Liu, Ching-Ti ; Borecki, Ingrid B ; North, Kari E ; Cupples, L Adrienne. / Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. In: Nature Communications. 2017 ; Vol. 8.
Bibtex
@article{52ae0d5b8b574320b7714af04148e46e,
title = "Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits",
abstract = "Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.",
keywords = "Journal Article",
author = "Justice, {Anne E} and Winkler, {Thomas W} and Feitosa, {Mary F} and Misa Graff and Fisher, {Virginia A} and Young, {Kristin L} and Llilda Barata and Xuan Deng and Jacek Czajkowski and David Hadley and Ngwa, {Julius S} and Ahluwalia, {Tarunveer Singh} and Chu, {Audrey Y} and Heard-Costa, {Nancy L} and Elise Lim and Jeremiah Perez and Eicher, {John D} and Zoltan Kutalik and Luting Xue and Anubha Mahajan and Frida Renstr{\"o}m and Wu, {Joseph C} and Qibin Qi and Shafqat Ahmad and Tamuno Alfred and Najaf Amin and Bielak, {Lawrence F} and Am{\'e}lie Bonnefond and Bragg-Gresham, {Jennifer L} and Gemma Cadby and Martina Chittani and Scott Coggeshall and Tanguy Corre and Nese Direk and Joel Eriksson and Krista Fischer and Mathias Gorski and {Neergaard Harder}, Marie and Momoko Horikoshi and Tao-wei Huang and Huffman, {Jennifer E} and Jackson, {Anne U} and Justesen, {Johanne Marie} and Stavroula Kanoni and Leena Kinnunen and Kleber, {Marcus E} and Pirjo Komulainen and Meena Kumari and Unhee Lim and Jian'an Luan and Leo-Pekka Lyytik{\"a}inen and Massimo Mangino and Ani Manichaikul and Jonathan Marten and Middelberg, {Rita P S} and Martina M{\"u}ller-Nurasyid and Pau Navarro and Louis P{\'e}russe and Natalia Pervjakova and Cinzia Sarti and Smith, {Albert Vernon} and Smith, {Jennifer A} and Alena Stan{\v c}{\'a}kov{\'a} and Strawbridge, {Rona J} and Stringham, {Heather M} and Sung, {Yun Ju} and Toshiko Tanaka and Alexander Teumer and Stella Trompet and {van der Laan}, {Sander W} and {van der Most}, {Peter J} and {van Vliet-Ostaptchouk}, {Jana V} and Vedantam, {Sailaja L} and Niek Verweij and Vink, {Jacqueline M} and Veronique Vitart and Ying Wu and Loic Yengo and Weihua Zhang and {Hua Zhao}, Jing and Zimmermann, {Martina E} and Niha Zubair and Abecasis, {Goncalo R} and Adair, {Linda S} and Saima Afaq and Uzma Afzal and Bakker, {Stephan J L} and Bartz, {Traci M} and John Beilby and Bergman, {Richard N} and Sven Bergmann and Reiner Biffar and John Blangero and Eric Boerwinkle and Bonnycastle, {Lori L} and Bottinger, {Erwin P} and Daniele Braga and Buckley, {Brendan M} and Steve Buyske and Harry Campbell and Chambers, {John C} and Collins, {Francis S} and Curran, {Joanne E} and {de Borst}, {Gert Jan} and {De Craen}, {Anton J M} and {de Geus}, {Eco J C} and George Dedoussis and Delgado, {Graciela E} and {den Ruijter}, {Hester M} and Gudny Eiriksdottir and Eriksson, {Anna L} and T{\~o}nu Esko and Faul, {Jessica D} and Ian Ford and Terrence Forrester and Karl Gertow and Bruna Gigante and Nicola Glorioso and Jian Gong and Harald Grallert and Grammer, {Tanja B} and Niels Grarup and Saskia Haitjema and G{\"o}ran Hallmans and Anders Hamsten and Torben Hansen and Harris, {Tamara B} and Hartman, {Catharina A} and Maija Hassinen and Hastie, {Nicholas D} and Heath, {Andrew C} and Dena Hernandez and Hindorff, {Lucia A} and Hocking, {Lynne J} and Mette Hollensted and Holmen, {Oddgeir L} and Georg Homuth and {Jan Hottenga}, Jouke and Jie Huang and Joseph Hung and Nina Hutri-K{\"a}h{\"o}nen and Erik Ingelsson and James, {Alan L} and John-Olov Jansson and Jarvelin, {Marjo Riitta} and Jhun, {Min A} and J{\o}rgensen, {Marit E} and Markus Juonala and Mika K{\"a}h{\"o}nen and Magnus Karlsson and Koistinen, {Heikki A} and Ivana Kolcic and Genovefa Kolovou and Charles Kooperberg and Kr{\"a}mer, {Bernhard K} and Johanna Kuusisto and Kirsti Kval{\o}y and Lakka, {Timo A} and Claudia Langenberg and Launer, {Lenore J} and Karin Leander and Lee, {Nanette R} and Lars Lind and Lindgren, {Cecilia M} and Allan Linneberg and St{\'e}phane Lobbens and Marie Loh and Mattias Lorentzon and Robert Luben and Gitta Lubke and Anja Ludolph-Donislawski and Sara Lupoli and Madden, {Pamela A F} and Reija M{\"a}nnikk{\"o} and Pedro Marques-Vidal and Martin, {Nicholas G.} and Mckenzie, {Colin A} and Barbara McKnight and Dan Mellstr{\"o}m and Cristina Menni and Montgomery, {Grant W.} and Musk, {Aw Bill} and Narisu Narisu and Matthias Nauck and Nolte, {Ilja M} and Oldehinkel, {Albertine J} and Matthias Olden and Ong, {Ken K} and Sandosh Padmanabhan and Peyser, {Patricia A} and Charlotta Pisinger and Porteous, {David J} and Raitakari, {Olli T} and Tuomo Rankinen and Rao, {Dabeeru C} and Rasmussen-Torvik, {Laura J} and Rajesh Rawal and Rice, {Treva K} and Ridker, {Paul M} and Rose, {Lynda M} and Bien, {Stephanie A} and Igor Rudan and Serena Sanna and Sarzynski, {Mark A} and Naveed Sattar and Kai Savonen and David Schlessinger and Salome Scholtens and Claudia Schurmann and Scott, {Robert A} and Bengt Sennblad and Siemelink, {Marten A} and G{\"u}nther Silbernagel and Slagboom, {P Eline} and Harold Snieder and Staessen, {Jan A.} and Stott, {David J} and Swertz, {Morris A} and Swift, {Amy J} and Taylor, {Kent D} and Tayo, {Bamidele O} and Barbara Thorand and Dorothee Thuillier and Jaakko Tuomilehto and Uitterlinden, {Andre G} and Liesbeth Vandenput and Marie-Claude Vohl and Henry V{\"o}lzke and Vonk, {Judith M} and Gerard Waeber and Melanie Waldenberger and Westendorp, {R G J} and Sarah Wild and Gonneke Willemsen and Wolffenbuttel, {Bruce H R} and Andrew Wong and Wright, {Alan F} and Wei Zhao and Zillikens, {M Carola} and Damiano Baldassarre and Beverley Balkau and Stefania Bandinelli and B{\"o}ger, {Carsten A} and Boomsma, {Dorret I} and Claude Bouchard and Marcel Bruinenberg and Chasman, {Daniel I} and Yii-DerIda Chen and Chines, {Peter S} and Cooper, {Richard S} and Francesco Cucca and Daniele Cusi and Faire, {Ulf de} and Luigi Ferrucci and Franks, {Paul W} and Philippe Froguel and Penny Gordon-Larsen and Grabe, {Hans J{\"o}rgen} and Vilmundur Gudnason and Haiman, {Christopher A} and Caroline Hayward and Kristian Hveem and Johnson, {Andrew D} and {Wouter Jukema}, J and Kardia, {Sharon L R} and Mika Kivimaki and Kooner, {Jaspal S} and Diana Kuh and Markku Laakso and Terho Lehtim{\"a}ki and Marchand, {Loic Le} and Winfried M{\"a}rz and McCarthy, {Mark I} and Andres Metspalu and Morris, {Andrew P} and Claes Ohlsson and Palmer, {Lyle J} and Gerard Pasterkamp and Oluf Pedersen and Annette Peters and Ulrike Peters and Ozren Polasek and Psaty, {Bruce M} and Lu Qi and Rainer Rauramaa and Smith, {Blair H} and S{\o}rensen, {Thorkild I A} and Konstantin Strauch and Henning Tiemeier and Elena Tremoli and {van der Harst}, Pim and Henrik Vestergaard and Peter Vollenweider and Wareham, {Nicholas J} and Weir, {David R} and Whitfield, {John B} and Wilson, {James F} and Jessica Tyrrell and Frayling, {Timothy M} and In{\^e}s Barroso and Michael Boehnke and Panagiotis Deloukas and Fox, {Caroline S} and Hirschhorn, {Joel N} and Hunter, {David J} and Spector, {Tim D} and Strachan, {David P} and {van Duijn}, {Corn{\'e}lia M} and Heid, {Iris M} and Mohlke, {Karen L} and Marchini, {Jonathan L} and Loos, {Ruth J F} and Kilpel{\"a}inen, {Tuomas O} and Ching-Ti Liu and Borecki, {Ingrid B} and North, {Kari E} and Cupples, {L Adrienne}",
year = "2017",
month = apr,
day = "26",
doi = "10.1038/ncomms14977",
language = "English",
volume = "8",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
AU - Justice, Anne E
AU - Winkler, Thomas W
AU - Feitosa, Mary F
AU - Graff, Misa
AU - Fisher, Virginia A
AU - Young, Kristin L
AU - Barata, Llilda
AU - Deng, Xuan
AU - Czajkowski, Jacek
AU - Hadley, David
AU - Ngwa, Julius S
AU - Ahluwalia, Tarunveer Singh
AU - Chu, Audrey Y
AU - Heard-Costa, Nancy L
AU - Lim, Elise
AU - Perez, Jeremiah
AU - Eicher, John D
AU - Kutalik, Zoltan
AU - Xue, Luting
AU - Mahajan, Anubha
AU - Renström, Frida
AU - Wu, Joseph C
AU - Qi, Qibin
AU - Ahmad, Shafqat
AU - Alfred, Tamuno
AU - Amin, Najaf
AU - Bielak, Lawrence F
AU - Bonnefond, Amélie
AU - Bragg-Gresham, Jennifer L
AU - Cadby, Gemma
AU - Chittani, Martina
AU - Coggeshall, Scott
AU - Corre, Tanguy
AU - Direk, Nese
AU - Eriksson, Joel
AU - Fischer, Krista
AU - Gorski, Mathias
AU - Neergaard Harder, Marie
AU - Horikoshi, Momoko
AU - Huang, Tao-wei
AU - Huffman, Jennifer E
AU - Jackson, Anne U
AU - Justesen, Johanne Marie
AU - Kanoni, Stavroula
AU - Kinnunen, Leena
AU - Kleber, Marcus E
AU - Komulainen, Pirjo
AU - Kumari, Meena
AU - Lim, Unhee
AU - Luan, Jian'an
AU - Lyytikäinen, Leo-Pekka
AU - Mangino, Massimo
AU - Manichaikul, Ani
AU - Marten, Jonathan
AU - Middelberg, Rita P S
AU - Müller-Nurasyid, Martina
AU - Navarro, Pau
AU - Pérusse, Louis
AU - Pervjakova, Natalia
AU - Sarti, Cinzia
AU - Smith, Albert Vernon
AU - Smith, Jennifer A
AU - Stančáková, Alena
AU - Strawbridge, Rona J
AU - Stringham, Heather M
AU - Sung, Yun Ju
AU - Tanaka, Toshiko
AU - Teumer, Alexander
AU - Trompet, Stella
AU - van der Laan, Sander W
AU - van der Most, Peter J
AU - van Vliet-Ostaptchouk, Jana V
AU - Vedantam, Sailaja L
AU - Verweij, Niek
AU - Vink, Jacqueline M
AU - Vitart, Veronique
AU - Wu, Ying
AU - Yengo, Loic
AU - Zhang, Weihua
AU - Hua Zhao, Jing
AU - Zimmermann, Martina E
AU - Zubair, Niha
AU - Abecasis, Goncalo R
AU - Adair, Linda S
AU - Afaq, Saima
AU - Afzal, Uzma
AU - Bakker, Stephan J L
AU - Bartz, Traci M
AU - Beilby, John
AU - Bergman, Richard N
AU - Bergmann, Sven
AU - Biffar, Reiner
AU - Blangero, John
AU - Boerwinkle, Eric
AU - Bonnycastle, Lori L
AU - Bottinger, Erwin P
AU - Braga, Daniele
AU - Buckley, Brendan M
AU - Buyske, Steve
AU - Campbell, Harry
AU - Chambers, John C
AU - Collins, Francis S
AU - Curran, Joanne E
AU - de Borst, Gert Jan
AU - De Craen, Anton J M
AU - de Geus, Eco J C
AU - Dedoussis, George
AU - Delgado, Graciela E
AU - den Ruijter, Hester M
AU - Eiriksdottir, Gudny
AU - Eriksson, Anna L
AU - Esko, Tõnu
AU - Faul, Jessica D
AU - Ford, Ian
AU - Forrester, Terrence
AU - Gertow, Karl
AU - Gigante, Bruna
AU - Glorioso, Nicola
AU - Gong, Jian
AU - Grallert, Harald
AU - Grammer, Tanja B
AU - Grarup, Niels
AU - Haitjema, Saskia
AU - Hallmans, Göran
AU - Hamsten, Anders
AU - Hansen, Torben
AU - Harris, Tamara B
AU - Hartman, Catharina A
AU - Hassinen, Maija
AU - Hastie, Nicholas D
AU - Heath, Andrew C
AU - Hernandez, Dena
AU - Hindorff, Lucia A
AU - Hocking, Lynne J
AU - Hollensted, Mette
AU - Holmen, Oddgeir L
AU - Homuth, Georg
AU - Jan Hottenga, Jouke
AU - Huang, Jie
AU - Hung, Joseph
AU - Hutri-Kähönen, Nina
AU - Ingelsson, Erik
AU - James, Alan L
AU - Jansson, John-Olov
AU - Jarvelin, Marjo Riitta
AU - Jhun, Min A
AU - Jørgensen, Marit E
AU - Juonala, Markus
AU - Kähönen, Mika
AU - Karlsson, Magnus
AU - Koistinen, Heikki A
AU - Kolcic, Ivana
AU - Kolovou, Genovefa
AU - Kooperberg, Charles
AU - Krämer, Bernhard K
AU - Kuusisto, Johanna
AU - Kvaløy, Kirsti
AU - Lakka, Timo A
AU - Langenberg, Claudia
AU - Launer, Lenore J
AU - Leander, Karin
AU - Lee, Nanette R
AU - Lind, Lars
AU - Lindgren, Cecilia M
AU - Linneberg, Allan
AU - Lobbens, Stéphane
AU - Loh, Marie
AU - Lorentzon, Mattias
AU - Luben, Robert
AU - Lubke, Gitta
AU - Ludolph-Donislawski, Anja
AU - Lupoli, Sara
AU - Madden, Pamela A F
AU - Männikkö, Reija
AU - Marques-Vidal, Pedro
AU - Martin, Nicholas G.
AU - Mckenzie, Colin A
AU - McKnight, Barbara
AU - Mellström, Dan
AU - Menni, Cristina
AU - Montgomery, Grant W.
AU - Musk, Aw Bill
AU - Narisu, Narisu
AU - Nauck, Matthias
AU - Nolte, Ilja M
AU - Oldehinkel, Albertine J
AU - Olden, Matthias
AU - Ong, Ken K
AU - Padmanabhan, Sandosh
AU - Peyser, Patricia A
AU - Pisinger, Charlotta
AU - Porteous, David J
AU - Raitakari, Olli T
AU - Rankinen, Tuomo
AU - Rao, Dabeeru C
AU - Rasmussen-Torvik, Laura J
AU - Rawal, Rajesh
AU - Rice, Treva K
AU - Ridker, Paul M
AU - Rose, Lynda M
AU - Bien, Stephanie A
AU - Rudan, Igor
AU - Sanna, Serena
AU - Sarzynski, Mark A
AU - Sattar, Naveed
AU - Savonen, Kai
AU - Schlessinger, David
AU - Scholtens, Salome
AU - Schurmann, Claudia
AU - Scott, Robert A
AU - Sennblad, Bengt
AU - Siemelink, Marten A
AU - Silbernagel, Günther
AU - Slagboom, P Eline
AU - Snieder, Harold
AU - Staessen, Jan A.
AU - Stott, David J
AU - Swertz, Morris A
AU - Swift, Amy J
AU - Taylor, Kent D
AU - Tayo, Bamidele O
AU - Thorand, Barbara
AU - Thuillier, Dorothee
AU - Tuomilehto, Jaakko
AU - Uitterlinden, Andre G
AU - Vandenput, Liesbeth
AU - Vohl, Marie-Claude
AU - Völzke, Henry
AU - Vonk, Judith M
AU - Waeber, Gerard
AU - Waldenberger, Melanie
AU - Westendorp, R G J
AU - Wild, Sarah
AU - Willemsen, Gonneke
AU - Wolffenbuttel, Bruce H R
AU - Wong, Andrew
AU - Wright, Alan F
AU - Zhao, Wei
AU - Zillikens, M Carola
AU - Baldassarre, Damiano
AU - Balkau, Beverley
AU - Bandinelli, Stefania
AU - Böger, Carsten A
AU - Boomsma, Dorret I
AU - Bouchard, Claude
AU - Bruinenberg, Marcel
AU - Chasman, Daniel I
AU - Chen, Yii-DerIda
AU - Chines, Peter S
AU - Cooper, Richard S
AU - Cucca, Francesco
AU - Cusi, Daniele
AU - Faire, Ulf de
AU - Ferrucci, Luigi
AU - Franks, Paul W
AU - Froguel, Philippe
AU - Gordon-Larsen, Penny
AU - Grabe, Hans Jörgen
AU - Gudnason, Vilmundur
AU - Haiman, Christopher A
AU - Hayward, Caroline
AU - Hveem, Kristian
AU - Johnson, Andrew D
AU - Wouter Jukema, J
AU - Kardia, Sharon L R
AU - Kivimaki, Mika
AU - Kooner, Jaspal S
AU - Kuh, Diana
AU - Laakso, Markku
AU - Lehtimäki, Terho
AU - Marchand, Loic Le
AU - März, Winfried
AU - McCarthy, Mark I
AU - Metspalu, Andres
AU - Morris, Andrew P
AU - Ohlsson, Claes
AU - Palmer, Lyle J
AU - Pasterkamp, Gerard
AU - Pedersen, Oluf
AU - Peters, Annette
AU - Peters, Ulrike
AU - Polasek, Ozren
AU - Psaty, Bruce M
AU - Qi, Lu
AU - Rauramaa, Rainer
AU - Smith, Blair H
AU - Sørensen, Thorkild I A
AU - Strauch, Konstantin
AU - Tiemeier, Henning
AU - Tremoli, Elena
AU - van der Harst, Pim
AU - Vestergaard, Henrik
AU - Vollenweider, Peter
AU - Wareham, Nicholas J
AU - Weir, David R
AU - Whitfield, John B
AU - Wilson, James F
AU - Tyrrell, Jessica
AU - Frayling, Timothy M
AU - Barroso, Inês
AU - Boehnke, Michael
AU - Deloukas, Panagiotis
AU - Fox, Caroline S
AU - Hirschhorn, Joel N
AU - Hunter, David J
AU - Spector, Tim D
AU - Strachan, David P
AU - van Duijn, Cornélia M
AU - Heid, Iris M
AU - Mohlke, Karen L
AU - Marchini, Jonathan L
AU - Loos, Ruth J F
AU - Kilpeläinen, Tuomas O
AU - Liu, Ching-Ti
AU - Borecki, Ingrid B
AU - North, Kari E
AU - Cupples, L Adrienne
PY - 2017/4/26
Y1 - 2017/4/26
N2 - Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
AB - Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, we use GWAS data from 51,080 current smokers and 190,178 nonsmokers (87% European descent) to identify loci influencing BMI and central adiposity, measured as waist circumference and waist-to-hip ratio both adjusted for BMI. We identify 23 novel genetic loci, and 9 loci with convincing evidence of gene-smoking interaction (GxSMK) on obesity-related traits. We show consistent direction of effect for all identified loci and significance for 18 novel and for 5 interaction loci in an independent study sample. These loci highlight novel biological functions, including response to oxidative stress, addictive behaviour, and regulatory functions emphasizing the importance of accounting for environment in genetic analyses. Our results suggest that tobacco smoking may alter the genetic susceptibility to overall adiposity and body fat distribution.
KW - Journal Article
U2 - 10.1038/ncomms14977
DO - 10.1038/ncomms14977
M3 - Journal article
C2 - 28443625
VL - 8
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 14977
ER -