Genome-wide association studies of human adiposity: Zooming in on synapses.
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Genome-wide association studies of human adiposity: Zooming in on synapses. / Sandholt, Camilla H.; Grarup, Niels; Pedersen, Oluf; Hansen, Torben.
In: Molecular and Cellular Endocrinology, Vol. 418, No. Part 2, 2015, p. 90-100.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genome-wide association studies of human adiposity: Zooming in on synapses.
AU - Sandholt, Camilla H.
AU - Grarup, Niels
AU - Pedersen, Oluf
AU - Hansen, Torben.
N1 - M1 - Copyright (C) 2015 American Chemical Society (ACS). All Rights Reserved. CAPLUS AN 2015:1879448(Journal; Online Computer File)
PY - 2015
Y1 - 2015
N2 - The decade anniversary for genome-wide assocn. studies (GWAS) is approaching, and this exptl. approach has commenced a deeper understanding of the genetics underlying complex diseases. In obesity genetics the GIANT (Genetic Investigation of ANthropometric Traits) consortium has played a crucial role, recently with two comprehensive meta-analyses, one focusing on general obesity, analyzing body-mass index (BMI) and the other on fat distribution, focusing on waist-hip ratio adjusted for BMI. With the in silico methods applied in these two studies as the pivot, this review looks into some of the biol. knowledge, beginning to emerge from the intricate genomic background behind the genetic determinants of human adiposity. These include synaptic dysfunction, where GWAS pinpoint potential new mechanisms in pathways already known to be linked with obesity.
AB - The decade anniversary for genome-wide assocn. studies (GWAS) is approaching, and this exptl. approach has commenced a deeper understanding of the genetics underlying complex diseases. In obesity genetics the GIANT (Genetic Investigation of ANthropometric Traits) consortium has played a crucial role, recently with two comprehensive meta-analyses, one focusing on general obesity, analyzing body-mass index (BMI) and the other on fat distribution, focusing on waist-hip ratio adjusted for BMI. With the in silico methods applied in these two studies as the pivot, this review looks into some of the biol. knowledge, beginning to emerge from the intricate genomic background behind the genetic determinants of human adiposity. These include synaptic dysfunction, where GWAS pinpoint potential new mechanisms in pathways already known to be linked with obesity.
U2 - 10.1016/j.mce.2015.09.029
DO - 10.1016/j.mce.2015.09.029
M3 - Journal article
C2 - 26427653
VL - 418
SP - 90
EP - 100
JO - Molecular and Cellular Endocrinology
JF - Molecular and Cellular Endocrinology
SN - 0303-7207
IS - Part 2
ER -
ID: 150703170