Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival: an IMMEnSE study
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Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival : an IMMEnSE study. / Campa, Daniele; Martino, Alessandro; Macauda, Angelica; Dudziński, Marek; Suska, Anna; Druzd-Sitek, Agnieszka; Raab, Marc-Steffen; Moreno, Victor; Huhn, Stefanie; Butrym, Aleksandra; Sainz, Juan; Szombath, Gergely; Rymko, Marcin; Marques, Herlander; Lesueur, Fabienne; Vangsted, Annette Juul; Vogel, Ulla; Kruszewski, Marcin; Subocz, Edyta; Buda, Gabriele; Iskierka-Jażdżewska, Elżbieta; Ríos, Rafael; Merz, Maximilian; Schöttker, Ben; Mazur, Grzegorz; Perrial, Emeline; Martinez-Lopez, Joaquin; Butterbach, Katja; García Sanz, Ramón; Goldschmidt, Hartmut; Brenner, Hermann; Jamroziak, Krzysztof; Reis, Rui Manuel; Kadar, Katalin; Dumontet, Charles; Wątek, Marzena; Haastrup, Eva Kannik; Helbig, Grzegorz; Jurczyszyn, Artur; Jerez, Andrés; Varkonyi, Judit; Barington, Torben; Grzasko, Norbert; Zaucha, Jan Maciej; Andersen, Vibeke; Zawirska, Daria; Canzian, Federico.
In: Leukemia and Lymphoma, Vol. 60, No. 7, 07.2019, p. 1803-1811.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Genetic polymorphisms in genes of class switch recombination and multiple myeloma risk and survival
T2 - an IMMEnSE study
AU - Campa, Daniele
AU - Martino, Alessandro
AU - Macauda, Angelica
AU - Dudziński, Marek
AU - Suska, Anna
AU - Druzd-Sitek, Agnieszka
AU - Raab, Marc-Steffen
AU - Moreno, Victor
AU - Huhn, Stefanie
AU - Butrym, Aleksandra
AU - Sainz, Juan
AU - Szombath, Gergely
AU - Rymko, Marcin
AU - Marques, Herlander
AU - Lesueur, Fabienne
AU - Vangsted, Annette Juul
AU - Vogel, Ulla
AU - Kruszewski, Marcin
AU - Subocz, Edyta
AU - Buda, Gabriele
AU - Iskierka-Jażdżewska, Elżbieta
AU - Ríos, Rafael
AU - Merz, Maximilian
AU - Schöttker, Ben
AU - Mazur, Grzegorz
AU - Perrial, Emeline
AU - Martinez-Lopez, Joaquin
AU - Butterbach, Katja
AU - García Sanz, Ramón
AU - Goldschmidt, Hartmut
AU - Brenner, Hermann
AU - Jamroziak, Krzysztof
AU - Reis, Rui Manuel
AU - Kadar, Katalin
AU - Dumontet, Charles
AU - Wątek, Marzena
AU - Haastrup, Eva Kannik
AU - Helbig, Grzegorz
AU - Jurczyszyn, Artur
AU - Jerez, Andrés
AU - Varkonyi, Judit
AU - Barington, Torben
AU - Grzasko, Norbert
AU - Zaucha, Jan Maciej
AU - Andersen, Vibeke
AU - Zawirska, Daria
AU - Canzian, Federico
PY - 2019/7
Y1 - 2019/7
N2 - Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.
AB - Genetic variants in genes acting during the maturation process of immature B-cell to differentiated plasma cell could influence the risk of developing multiple myeloma (MM). During B-cell maturation, several programmed genetic rearrangements occur to increase the variation of the immunoglobulin chains. Class switch recombination (CSR) is one of the most important among these mechanisms. Germline polymorphisms altering even subtly this process could play a role in the etiology and outcome of MM. We performed an association study of 30 genetic variants in the key CSR genes, using 2632 MM patients and 2848 controls from the International Multiple Myeloma rESEarch (IMMEnSE) consortium, the Heidelberg MM Group and the ESTHER cohort. We found an association between LIG4-rs1555902 and decreased MM risk, which approached statistical significance, as well as significant associations between AICDA-rs3794318 and better outcome. Our results add to our knowledge on the genetic component of MM risk and survival.
U2 - 10.1080/10428194.2018.1551536
DO - 10.1080/10428194.2018.1551536
M3 - Journal article
C2 - 30633655
VL - 60
SP - 1803
EP - 1811
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 7
ER -
ID: 235916431