Genetic assortative mating for schizophrenia and bipolar disorder

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Genetic assortative mating for schizophrenia and bipolar disorder. / Jefsen, Oskar Hougaard; Nudel, Ron; Wang, Yunpeng; Bybjerg-Grauholm, Jonas; Hemager, Nicoline; Christiani, Camilla A. J.; Burton, Birgitte K.; Spang, Katrine S.; Ellersgaard, Ditte; Gantriis, Ditte L.; Plessen, Kerstin Jessica; Jepsen, Jens Richardt M.; Thorup, Anne A. E.; Werge, Thomas; Nordentoft, Merete; Mors, Ole; Greve, Aja Neergaard.

In: European Psychiatry, Vol. 65, No. 1, e53, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jefsen, OH, Nudel, R, Wang, Y, Bybjerg-Grauholm, J, Hemager, N, Christiani, CAJ, Burton, BK, Spang, KS, Ellersgaard, D, Gantriis, DL, Plessen, KJ, Jepsen, JRM, Thorup, AAE, Werge, T, Nordentoft, M, Mors, O & Greve, AN 2022, 'Genetic assortative mating for schizophrenia and bipolar disorder', European Psychiatry, vol. 65, no. 1, e53. https://doi.org/10.1192/j.eurpsy.2022.2304

APA

Jefsen, O. H., Nudel, R., Wang, Y., Bybjerg-Grauholm, J., Hemager, N., Christiani, C. A. J., Burton, B. K., Spang, K. S., Ellersgaard, D., Gantriis, D. L., Plessen, K. J., Jepsen, J. R. M., Thorup, A. A. E., Werge, T., Nordentoft, M., Mors, O., & Greve, A. N. (2022). Genetic assortative mating for schizophrenia and bipolar disorder. European Psychiatry, 65(1), [e53]. https://doi.org/10.1192/j.eurpsy.2022.2304

Vancouver

Jefsen OH, Nudel R, Wang Y, Bybjerg-Grauholm J, Hemager N, Christiani CAJ et al. Genetic assortative mating for schizophrenia and bipolar disorder. European Psychiatry. 2022;65(1). e53. https://doi.org/10.1192/j.eurpsy.2022.2304

Author

Jefsen, Oskar Hougaard ; Nudel, Ron ; Wang, Yunpeng ; Bybjerg-Grauholm, Jonas ; Hemager, Nicoline ; Christiani, Camilla A. J. ; Burton, Birgitte K. ; Spang, Katrine S. ; Ellersgaard, Ditte ; Gantriis, Ditte L. ; Plessen, Kerstin Jessica ; Jepsen, Jens Richardt M. ; Thorup, Anne A. E. ; Werge, Thomas ; Nordentoft, Merete ; Mors, Ole ; Greve, Aja Neergaard. / Genetic assortative mating for schizophrenia and bipolar disorder. In: European Psychiatry. 2022 ; Vol. 65, No. 1.

Bibtex

@article{dfe759ebc1734369bcb0999aaa2374b4,

title = "Genetic assortative mating for schizophrenia and bipolar disorder",

abstract = "Background: Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRS). Methods: Polygenic risk scores from The Danish High-Risk and Resilience Study-VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results: The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed significant correlation between parent pairs (r = 0.121, p = 0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r = 0.162, p = 0.0067), but was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions: Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.",

keywords = "Assortative mating, Bipolar disorder, Partner resemblance, Polygenic risk scores, Schizophrenia",

author = "Jefsen, {Oskar Hougaard} and Ron Nudel and Yunpeng Wang and Jonas Bybjerg-Grauholm and Nicoline Hemager and Christiani, {Camilla A. J.} and Burton, {Birgitte K.} and Spang, {Katrine S.} and Ditte Ellersgaard and Gantriis, {Ditte L.} and Plessen, {Kerstin Jessica} and Jepsen, {Jens Richardt M.} and Thorup, {Anne A. E.} and Thomas Werge and Merete Nordentoft and Ole Mors and Greve, {Aja Neergaard}",

year = "2022",

doi = "10.1192/j.eurpsy.2022.2304",

language = "English",

volume = "65",

journal = "European Psychiatry",

issn = "0924-9338",

publisher = "Elsevier Masson",

number = "1",

}

RIS

TY - JOUR

T1 - Genetic assortative mating for schizophrenia and bipolar disorder

AU - Jefsen, Oskar Hougaard

AU - Nudel, Ron

AU - Wang, Yunpeng

AU - Bybjerg-Grauholm, Jonas

AU - Hemager, Nicoline

AU - Christiani, Camilla A. J.

AU - Burton, Birgitte K.

AU - Spang, Katrine S.

AU - Ellersgaard, Ditte

AU - Gantriis, Ditte L.

AU - Plessen, Kerstin Jessica

AU - Jepsen, Jens Richardt M.

AU - Thorup, Anne A. E.

AU - Werge, Thomas

AU - Nordentoft, Merete

AU - Mors, Ole

AU - Greve, Aja Neergaard

PY - 2022

Y1 - 2022

N2 - Background: Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRS). Methods: Polygenic risk scores from The Danish High-Risk and Resilience Study-VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results: The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed significant correlation between parent pairs (r = 0.121, p = 0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r = 0.162, p = 0.0067), but was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions: Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.

AB - Background: Psychiatric disorders are highly polygenic and show patterns of partner resemblance. Partner resemblance has direct population-level genetic implications if it is caused by assortative mating, but not if it is caused by convergence or social homogamy. Using genetics may help distinguish these different mechanisms. Here, we investigated whether partner resemblance for schizophrenia and bipolar disorder is influenced by assortative mating using polygenic risk scores (PRS). Methods: Polygenic risk scores from The Danish High-Risk and Resilience Study-VIA 7 were compared between parents in three subsamples: population-based control parent pairs (N=198), parent pairs where at least one parent had schizophrenia (N=193), and parent pairs where at least one parent had bipolar disorder (N=115). Results: The PRS for schizophrenia was predictive of schizophrenia in the full sample and showed significant correlation between parent pairs (r = 0.121, p = 0.0440), indicative of assortative mating. The PRS for bipolar disorder was also correlated between parent pairs (r = 0.162, p = 0.0067), but was not predictive of bipolar disorder in the full sample, limiting the interpretation. Conclusions: Our study provides genetic evidence for assortative mating for schizophrenia, with important implications for our understanding of the genetics of schizophrenia.

KW - Assortative mating

KW - Bipolar disorder

KW - Partner resemblance

KW - Polygenic risk scores

KW - Schizophrenia

U2 - 10.1192/j.eurpsy.2022.2304

DO - 10.1192/j.eurpsy.2022.2304

M3 - Journal article

C2 - 35996886

AN - SCOPUS:85136974642

VL - 65

JO - European Psychiatry

JF - European Psychiatry

SN - 0924-9338

IS - 1

M1 - e53

ER -

ID: 320758763

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