Genetic architecture of obesity and related metabolic traits - recent insights from isolated populations
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Genetic architecture of obesity and related metabolic traits - recent insights from isolated populations. / Andersen, Mette Korre; Grarup, Niels; Moltke, Ida; Albrechtsen, Anders; Hansen, Torben.
In: Current Opinion in Genetics and Development, Vol. 50, 2018, p. 74-78.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Genetic architecture of obesity and related metabolic traits - recent insights from isolated populations
AU - Andersen, Mette Korre
AU - Grarup, Niels
AU - Moltke, Ida
AU - Albrechtsen, Anders
AU - Hansen, Torben
PY - 2018
Y1 - 2018
N2 - In this mini-review, we give an overview of what is known about the genetic architecture of obesity and related metabolic traits with a primary focus on recent insights from studies of historically small and isolated populations. We start by briefly explaining what genetic architecture is and why studies of isolated populations in general are valuable if we want a complete picture of the genetic architecture of diseases and other traits among humans. Then we contrast what is known about the genetic architecture of obesity and related metabolic traits among large outbred populations, like Europeans, with results from recent studies of isolated populations. Finally, we briefly discuss the perspectives of studying isolated populations to gain insight into genetic architecture in humans.
AB - In this mini-review, we give an overview of what is known about the genetic architecture of obesity and related metabolic traits with a primary focus on recent insights from studies of historically small and isolated populations. We start by briefly explaining what genetic architecture is and why studies of isolated populations in general are valuable if we want a complete picture of the genetic architecture of diseases and other traits among humans. Then we contrast what is known about the genetic architecture of obesity and related metabolic traits among large outbred populations, like Europeans, with results from recent studies of isolated populations. Finally, we briefly discuss the perspectives of studying isolated populations to gain insight into genetic architecture in humans.
U2 - 10.1016/j.gde.2018.02.010
DO - 10.1016/j.gde.2018.02.010
M3 - Review
C2 - 29510341
AN - SCOPUS:85042689011
VL - 50
SP - 74
EP - 78
JO - Current Opinion in Genetics & Development
JF - Current Opinion in Genetics & Development
SN - 0959-437X
ER -
ID: 200857894