Gene expression heterogeneities in embryonic stem cell populations: origin and function

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Gene expression heterogeneities in embryonic stem cell populations : origin and function. / Martinez Arias, Alfonso; Brickman, Joshua M.

In: Current Opinion in Cell Biology, Vol. 23, No. 6, 12.2011, p. 650-6.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Martinez Arias, A & Brickman, JM 2011, 'Gene expression heterogeneities in embryonic stem cell populations: origin and function', Current Opinion in Cell Biology, vol. 23, no. 6, pp. 650-6. https://doi.org/10.1016/j.ceb.2011.09.007

APA

Martinez Arias, A., & Brickman, J. M. (2011). Gene expression heterogeneities in embryonic stem cell populations: origin and function. Current Opinion in Cell Biology, 23(6), 650-6. https://doi.org/10.1016/j.ceb.2011.09.007

Vancouver

Martinez Arias A, Brickman JM. Gene expression heterogeneities in embryonic stem cell populations: origin and function. Current Opinion in Cell Biology. 2011 Dec;23(6):650-6. https://doi.org/10.1016/j.ceb.2011.09.007

Author

Martinez Arias, Alfonso ; Brickman, Joshua M. / Gene expression heterogeneities in embryonic stem cell populations : origin and function. In: Current Opinion in Cell Biology. 2011 ; Vol. 23, No. 6. pp. 650-6.

Bibtex

@article{eef8bf938707419389eaa2cd07d5c375,
title = "Gene expression heterogeneities in embryonic stem cell populations: origin and function",
abstract = "Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.",
keywords = "Cell Differentiation, Cell Division, Cell Line, Embryonic Stem Cells, Gene Expression Regulation, Developmental, Hematopoietic Stem Cells, Humans",
author = "{Martinez Arias}, Alfonso and Brickman, {Joshua M}",
note = "Copyright {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
month = dec,
doi = "10.1016/j.ceb.2011.09.007",
language = "English",
volume = "23",
pages = "650--6",
journal = "Current Opinion in Cell Biology",
issn = "0955-0674",
publisher = "Elsevier Ltd. * Current Opinion Journals",
number = "6",

}

RIS

TY - JOUR

T1 - Gene expression heterogeneities in embryonic stem cell populations

T2 - origin and function

AU - Martinez Arias, Alfonso

AU - Brickman, Joshua M

N1 - Copyright © 2011 Elsevier Ltd. All rights reserved.

PY - 2011/12

Y1 - 2011/12

N2 - Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.

AB - Stem and progenitor cells are populations of cells that retain the capacity to populate specific lineages and to transit this capacity through cell division. However, attempts to define markers for stem cells have met with limited success. Here we consider whether this limited success reflects an intrinsic requirement for heterogeneity with stem cell populations. We focus on Embryonic Stem (ES) cells, in vitro derived cell lines from the early embryo that are considered both pluripotent (able to generate all the lineages of the future embryo) and indefinitely self renewing. We examine the relevance of recently reported heterogeneities in ES cells and whether these heterogeneities themselves are inherent requirements of functional potency and self renewal.

KW - Cell Differentiation

KW - Cell Division

KW - Cell Line

KW - Embryonic Stem Cells

KW - Gene Expression Regulation, Developmental

KW - Hematopoietic Stem Cells

KW - Humans

U2 - 10.1016/j.ceb.2011.09.007

DO - 10.1016/j.ceb.2011.09.007

M3 - Journal article

C2 - 21982544

VL - 23

SP - 650

EP - 656

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

SN - 0955-0674

IS - 6

ER -

ID: 129061835