Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue

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Standard

Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue. / Petersen, O. W.; Høyer, P. E.; Van Deurs, B.

In: Cancer Research, Vol. 47, No. 21, 1987, p. 5748-5751.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Petersen, OW, Høyer, PE & Van Deurs, B 1987, 'Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue', Cancer Research, vol. 47, no. 21, pp. 5748-5751.

APA

Petersen, O. W., Høyer, P. E., & Van Deurs, B. (1987). Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue. Cancer Research, 47(21), 5748-5751.

Vancouver

Petersen OW, Høyer PE, Van Deurs B. Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue. Cancer Research. 1987;47(21):5748-5751.

Author

Petersen, O. W. ; Høyer, P. E. ; Van Deurs, B. / Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue. In: Cancer Research. 1987 ; Vol. 47, No. 21. pp. 5748-5751.

Bibtex

@article{7369b514ed3442e5b6acb585cee03c4a,
title = "Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue",
abstract = "We have analyzed the frequency and distribution of cells expressing estrogen receptor (ER) in cryosections of normal human breast tissue using quantitative microspectrophotometry and the estrogen receptor immunocytochemical assay. We found that the human mammary gland contained a small but distinct population of ER-positive cells, comprising approximately 7% of the total epithelial cell population from all biopsies. Stromal cells were found to be ER negative. The ER-positive cells were distributed as scattered single cells, with the highest frequency and intensity of measured staining in the lobules as compared to the interlobular ducts. Moreover, on the average, 87% of the ER-positive cells were luminal epithelial cells or occupied an intermediate position in the duct wall. The intermediate cells were found not to express basal cell phenotype as determined by combined immunocytochemistry to ER and “common acute lymphoblastic leukemia antigen” selectively decorating myoepithelial cells (B. A. Gusterson et aL, J. Natl. Cancer Inst., 77; 343-349, 1986).",
author = "Petersen, {O. W.} and H{\o}yer, {P. E.} and {Van Deurs}, B.",
year = "1987",
language = "English",
volume = "47",
pages = "5748--5751",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "21",

}

RIS

TY - JOUR

T1 - Frequency and distribution of estrogen receptor-positive cells in normal, nonlactating human breast tissue

AU - Petersen, O. W.

AU - Høyer, P. E.

AU - Van Deurs, B.

PY - 1987

Y1 - 1987

N2 - We have analyzed the frequency and distribution of cells expressing estrogen receptor (ER) in cryosections of normal human breast tissue using quantitative microspectrophotometry and the estrogen receptor immunocytochemical assay. We found that the human mammary gland contained a small but distinct population of ER-positive cells, comprising approximately 7% of the total epithelial cell population from all biopsies. Stromal cells were found to be ER negative. The ER-positive cells were distributed as scattered single cells, with the highest frequency and intensity of measured staining in the lobules as compared to the interlobular ducts. Moreover, on the average, 87% of the ER-positive cells were luminal epithelial cells or occupied an intermediate position in the duct wall. The intermediate cells were found not to express basal cell phenotype as determined by combined immunocytochemistry to ER and “common acute lymphoblastic leukemia antigen” selectively decorating myoepithelial cells (B. A. Gusterson et aL, J. Natl. Cancer Inst., 77; 343-349, 1986).

AB - We have analyzed the frequency and distribution of cells expressing estrogen receptor (ER) in cryosections of normal human breast tissue using quantitative microspectrophotometry and the estrogen receptor immunocytochemical assay. We found that the human mammary gland contained a small but distinct population of ER-positive cells, comprising approximately 7% of the total epithelial cell population from all biopsies. Stromal cells were found to be ER negative. The ER-positive cells were distributed as scattered single cells, with the highest frequency and intensity of measured staining in the lobules as compared to the interlobular ducts. Moreover, on the average, 87% of the ER-positive cells were luminal epithelial cells or occupied an intermediate position in the duct wall. The intermediate cells were found not to express basal cell phenotype as determined by combined immunocytochemistry to ER and “common acute lymphoblastic leukemia antigen” selectively decorating myoepithelial cells (B. A. Gusterson et aL, J. Natl. Cancer Inst., 77; 343-349, 1986).

UR - http://www.scopus.com/inward/record.url?scp=0023576146&partnerID=8YFLogxK

M3 - Journal article

C2 - 3664479

AN - SCOPUS:0023576146

VL - 47

SP - 5748

EP - 5751

JO - Cancer Research

JF - Cancer Research

SN - 0008-5472

IS - 21

ER -

ID: 347535570