First trimester maternal serum PAPP-A, beta-hCG and ADAM12 in prediction of small-for-gestational-age fetuses
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First trimester maternal serum PAPP-A, beta-hCG and ADAM12 in prediction of small-for-gestational-age fetuses. / Pihl, Kasper; Larsen, Torben; Krebs, Lone; Christiansen, Michael.
In: Prenatal Diagnosis, Vol. 28, No. 12, 12.2008, p. 1131-5.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - First trimester maternal serum PAPP-A, beta-hCG and ADAM12 in prediction of small-for-gestational-age fetuses
AU - Pihl, Kasper
AU - Larsen, Torben
AU - Krebs, Lone
AU - Christiansen, Michael
N1 - Copyright (c) 2008 John Wiley & Sons, Ltd.
PY - 2008/12
Y1 - 2008/12
N2 - OBJECTIVE: To examine the ability of predicting fetuses being small-for-gestational-age (SGA) at delivery with the maternal serum markers pregnancy-associated plasma protein A (PAPP-A), beta-human chorionic gonadotrophin (beta-hCG) and A disintegrin and metalloprotease 12 (ADAM12) in first trimester.METHODS: In all,36 cases being SGA (birth weight < 5th centile) and 108 controls being non-SGA were matched on ethnicity (only Caucasians), smoking status (only nonsmokers), body mass index (BMI), age and parity. Stored blood samples from PAPP-A and beta-hCG testing obtained at gestational age (GA) of 8 weeks to 13 weeks and 6 days were analyzed for ADAM12. Median MoM values were compared using Mann-Whitney test. Monte Carlo estimation and receiver-operator-characteristics curves were used to asses screening performance.RESULTS: Median MoM values of PAPP-A (0.64 vs 1.02, p < 0.001), beta-hCG (0.74 vs 1.04, p = 0.007) and ADAM12 (0.74 vs 0.97, p = 0.004) were significantly reduced in cases compared to controls. The combination of PAPP-A MoM and beta-hCG MoM yielded a detection rate (DR) for SGA of 26% for a 5% false-positive rate (FPR). Addition of ADAM12 only improved (28% DR for a 5% FPR) screening performance modestly.CONCLUSION: Early prediction of fetuses being SGA is feasible with the combination of first trimester PAPP-A, beta-hCG and ADAM12. Screening performance is approaching clinical relevance. The inclusion of further markers is an attractive option.
AB - OBJECTIVE: To examine the ability of predicting fetuses being small-for-gestational-age (SGA) at delivery with the maternal serum markers pregnancy-associated plasma protein A (PAPP-A), beta-human chorionic gonadotrophin (beta-hCG) and A disintegrin and metalloprotease 12 (ADAM12) in first trimester.METHODS: In all,36 cases being SGA (birth weight < 5th centile) and 108 controls being non-SGA were matched on ethnicity (only Caucasians), smoking status (only nonsmokers), body mass index (BMI), age and parity. Stored blood samples from PAPP-A and beta-hCG testing obtained at gestational age (GA) of 8 weeks to 13 weeks and 6 days were analyzed for ADAM12. Median MoM values were compared using Mann-Whitney test. Monte Carlo estimation and receiver-operator-characteristics curves were used to asses screening performance.RESULTS: Median MoM values of PAPP-A (0.64 vs 1.02, p < 0.001), beta-hCG (0.74 vs 1.04, p = 0.007) and ADAM12 (0.74 vs 0.97, p = 0.004) were significantly reduced in cases compared to controls. The combination of PAPP-A MoM and beta-hCG MoM yielded a detection rate (DR) for SGA of 26% for a 5% false-positive rate (FPR). Addition of ADAM12 only improved (28% DR for a 5% FPR) screening performance modestly.CONCLUSION: Early prediction of fetuses being SGA is feasible with the combination of first trimester PAPP-A, beta-hCG and ADAM12. Screening performance is approaching clinical relevance. The inclusion of further markers is an attractive option.
KW - ADAM Proteins
KW - ADAM12 Protein
KW - Adolescent
KW - Adult
KW - Case-Control Studies
KW - Chorionic Gonadotropin, beta Subunit, Human
KW - Cohort Studies
KW - Feasibility Studies
KW - Female
KW - Fetal Growth Retardation
KW - Humans
KW - Infant, Newborn
KW - Infant, Small for Gestational Age
KW - Membrane Proteins
KW - Mothers
KW - Pregnancy
KW - Pregnancy Trimester, First
KW - Pregnancy-Associated Plasma Protein-A
KW - Prenatal Diagnosis
KW - Young Adult
KW - Evaluation Studies
KW - Journal Article
U2 - 10.1002/pd.2141
DO - 10.1002/pd.2141
M3 - Journal article
C2 - 19003798
VL - 28
SP - 1131
EP - 1135
JO - Prenatal Diagnosis
JF - Prenatal Diagnosis
SN - 0197-3851
IS - 12
ER -
ID: 179628773