Extrachromosomal circular DNA in cancer: history, current knowledge, and methods
Research output: Contribution to journal › Review › Research › peer-review
Documents
- Fulltext
Final published version, 1.6 MB, PDF document
Extrachromosomal circular DNA (eccDNA) is a closed-circle, nuclear, nonplasmid DNA molecule found in all tested eukaryotes. eccDNA plays important roles in cancer pathogenesis, evolution of tumor heterogeneity, and therapeutic resistance. It is known under many names, including very large cancer-specific circular extrachromosomal DNA (ecDNA), which carries oncogenes and is often amplified in cancer cells. Our understanding of eccDNA has historically been limited and fragmented. To provide better a context of new and previous research on eccDNA, in this review we give an overview of the various names given to eccDNA at different times. We describe the different mechanisms for formation of eccDNA and the methods used to study eccDNA thus far. Finally, we explore the potential clinical value of eccDNA.
Original language | English |
---|---|
Journal | Trends in Genetics |
Volume | 38 |
Issue number | 7 |
Pages (from-to) | 766-781 |
Number of pages | 16 |
ISSN | 0168-9525 |
DOIs | |
Publication status | Published - 2022 |
Bibliographical note
Publisher Copyright:
© 2022 The Authors
- copy number variation, DNA damage, double minutes, eccDNA, ecDNA, oncogene amplification
Research areas
Number of downloads are based on statistics from Google Scholar and www.ku.dk
ID: 304021853