Establishment and functions of DNA methylation in the germline
Research output: Contribution to journal › Review › Research › peer-review
Standard
Establishment and functions of DNA methylation in the germline. / Stewart-Morgan, Kathleen; Veselovska, Lenka; Kelsey, Gavin.
In: Epigenomics, Vol. 8, No. 10, 2016, p. 1399-1413.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Establishment and functions of DNA methylation in the germline
AU - Stewart-Morgan, Kathleen
AU - Veselovska, Lenka
AU - Kelsey, Gavin
PY - 2016
Y1 - 2016
N2 - Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.
AB - Epigenetic modifications established during gametogenesis regulate transcription and other nuclear processes in gametes, but also have influences in the zygote, embryo and postnatal life. This is best understood for DNA methylation which, established at discrete regions of the oocyte and sperm genomes, governs genomic imprinting. In this review, we describe how imprinting has informed our understanding of de novo DNA methylation mechanisms, highlight how recent genome-wide profiling studies have provided unprecedented insights into establishment of the sperm and oocyte methylomes and consider the fate and function of gametic methylation and other epigenetic modifications after fertilization.
KW - DNA methylation
KW - embryo
KW - imprinting
KW - oogenesis
KW - spermatogenesis
KW - transgenerational inheritance
U2 - 10.2217/epi-2016-0056
DO - 10.2217/epi-2016-0056
M3 - Review
C2 - 27659720
AN - SCOPUS:84990821386
VL - 8
SP - 1399
EP - 1413
JO - Epigenomics
JF - Epigenomics
SN - 1750-1911
IS - 10
ER -
ID: 179132271