Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy
Research output: Contribution to journal › Journal article › Research › peer-review
There is emerging evidence that early trauma-induced coagulopathy (TIC) is mechanistically linked to disruption of the vascular endothelium and its glycocalyx, assessed by thrombomodulin and syndecan 1, respectively. This study evaluated if degradation of the endothelial glycocalyx and ensuing release of its heparin-like substances induce autoheparinization and thereby contributes to TIC.
Original language | English |
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Journal | Journal of Trauma |
Volume | 73 |
Issue number | 1 |
Pages (from-to) | 60-6 |
Number of pages | 7 |
ISSN | 0022-5282 |
DOIs | |
Publication status | Published - 2012 |
ID: 48549213