Elevation of Pro-Inflammatory Cytokine Levels Following Intra-Articular Fractures-A Systematic Review
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Elevation of Pro-Inflammatory Cytokine Levels Following Intra-Articular Fractures-A Systematic Review. / Pham, That Minh; Erichsen, Julie Ladeby; Kowal, Justyna Magdalena; Overgaard, Søren; Schmal, Hagen.
In: Cells, Vol. 10, No. 4, 902, 2021.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - Elevation of Pro-Inflammatory Cytokine Levels Following Intra-Articular Fractures-A Systematic Review
AU - Pham, That Minh
AU - Erichsen, Julie Ladeby
AU - Kowal, Justyna Magdalena
AU - Overgaard, Søren
AU - Schmal, Hagen
PY - 2021
Y1 - 2021
N2 - Introduction: Intra-articular fractures are a major cause of post-traumatic osteoarthritis (PTOA). Despite adequate surgical treatment, the long-term risk for PTOA is high. Previous studies reported that joint injuries initiate an inflammatory cascade characterized by an elevation of synovial pro-inflammatory cytokines, which can lead to cartilage degradation and PTOA development. This review summarizes the literature on the post-injury regulation of pro-inflammatory cytokines and the markers of cartilage destruction in patients suffering from intra-articular fractures. Methods: We searched Medline, Embase, and Cochrane databases (1960-February 2020) and included studies that were performed on human participants, and we included control groups. Two investigators assessed the quality of the included studies using Covidence and the Newcastle-Ottawa Scale. Results: Based on the surveyed literature, several synovial pro-inflammatory cytokines, including interleukins (IL)-1β, IL-2, IL-6, IL-8, IL-12p70, interferon-y, and tumor necrosis factor-α, were significantly elevated in patients suffering from intra-articular fractures compared to the control groups. A simultaneous elevation of anti-inflammatory cytokines such as IL-10 and IL-1RA was also observed. In contrast, IL-13, CTX-II, and aggrecan concentrations did not differ significantly between the compared cohorts. Conclusions: Overall, intra-articular fractures are associated with an increase in inflammation-related synovial cytokines. However, more standardized studies which focus on the ratio of pro- and anti-inflammatory cytokines at different time points are needed.
AB - Introduction: Intra-articular fractures are a major cause of post-traumatic osteoarthritis (PTOA). Despite adequate surgical treatment, the long-term risk for PTOA is high. Previous studies reported that joint injuries initiate an inflammatory cascade characterized by an elevation of synovial pro-inflammatory cytokines, which can lead to cartilage degradation and PTOA development. This review summarizes the literature on the post-injury regulation of pro-inflammatory cytokines and the markers of cartilage destruction in patients suffering from intra-articular fractures. Methods: We searched Medline, Embase, and Cochrane databases (1960-February 2020) and included studies that were performed on human participants, and we included control groups. Two investigators assessed the quality of the included studies using Covidence and the Newcastle-Ottawa Scale. Results: Based on the surveyed literature, several synovial pro-inflammatory cytokines, including interleukins (IL)-1β, IL-2, IL-6, IL-8, IL-12p70, interferon-y, and tumor necrosis factor-α, were significantly elevated in patients suffering from intra-articular fractures compared to the control groups. A simultaneous elevation of anti-inflammatory cytokines such as IL-10 and IL-1RA was also observed. In contrast, IL-13, CTX-II, and aggrecan concentrations did not differ significantly between the compared cohorts. Conclusions: Overall, intra-articular fractures are associated with an increase in inflammation-related synovial cytokines. However, more standardized studies which focus on the ratio of pro- and anti-inflammatory cytokines at different time points are needed.
KW - biomarkers
KW - cartilage
KW - cytokines
KW - inflammatory
KW - intra-articular fracture
KW - joint injury
KW - osteoarthritis
KW - synovial fluid
U2 - 10.3390/cells10040902
DO - 10.3390/cells10040902
M3 - Review
C2 - 33919965
AN - SCOPUS:85105245205
VL - 10
JO - Cells
JF - Cells
SN - 2073-4409
IS - 4
M1 - 902
ER -
ID: 262802311