Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
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Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon. / Jeppesen, P B; Hartmann, B; Thulesen, J; Hansen, B S; Holst, J J; Poulsen, Steen Seier; Mortensen, P B.
In: Gut, Vol. 47, No. 3, 09.2000, p. 370-6.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Elevated plasma glucagon-like peptide 1 and 2 concentrations in ileum resected short bowel patients with a preserved colon
AU - Jeppesen, P B
AU - Hartmann, B
AU - Thulesen, J
AU - Hansen, B S
AU - Holst, J J
AU - Poulsen, Steen Seier
AU - Mortensen, P B
PY - 2000/9
Y1 - 2000/9
N2 - The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.
AB - The glucagon-like peptides (GLP) 1 and 2 are secreted postprandially from L cells located mainly in the ileum. Both hormones prolong intestinal transit and GLP-2 is intestinotrophic in rodents. Patients with a jejunostomy have poor adaptation, rapid gastric and intestinal transit, and impaired postprandial GLP-2 secretion. Ileum resected short bowel patients with a preserved colon show evidence of functional adaptation and have normal gastric emptying.
KW - Adaptation, Physiological
KW - Adult
KW - Aged
KW - Area Under Curve
KW - Case-Control Studies
KW - Fasting
KW - Female
KW - Glucagon
KW - Glucagon-Like Peptide 1
KW - Glucagon-Like Peptide 2
KW - Humans
KW - Ileum
KW - Male
KW - Middle Aged
KW - Peptide Fragments
KW - Peptides
KW - Postprandial Period
KW - Protein Precursors
KW - Radioimmunoassay
KW - Short Bowel Syndrome
M3 - Journal article
C2 - 10940274
VL - 47
SP - 370
EP - 376
JO - Gut
JF - Gut
SN - 0017-5749
IS - 3
ER -
ID: 47486403