Effects of Sleep Deprivation on Blood Glucose, Food Cravings, and Affect in a Non-Diabetic: An N-of-1 Randomized Pilot Study
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Effects of Sleep Deprivation on Blood Glucose, Food Cravings, and Affect in a Non-Diabetic : An N-of-1 Randomized Pilot Study. / Daza, Eric Jay; Wac, Katarzyna; Oppezzo, Marily.
In: Healthcare, Vol. 8, No. 1, 6, 2020.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of Sleep Deprivation on Blood Glucose, Food Cravings, and Affect in a Non-Diabetic
T2 - An N-of-1 Randomized Pilot Study
AU - Daza, Eric Jay
AU - Wac, Katarzyna
AU - Oppezzo, Marily
PY - 2020
Y1 - 2020
N2 - Abstract: Sleep deprivation is a prevalent and rising health concern, one with known effects on blood glucose (BG) levels, mood, and calorie consumption. However, the mechanisms by which sleep deprivation affects calorie consumption (e.g., measured via self-reported types craved food) are unclear, and may be highly idiographic (i.e., individual specific). Single-case or "n-of-1" randomized trials (N1RT) are useful in exploring such effects by exposing each subject to both sleep deprivation and baseline conditions, thereby characterizing effects specific to that individual. We had two objectives: (1) To test and generate individual-specific N1RT hypotheses of the effects of sleep deprivation on next-day BG level, mood, and food cravings in two non-diabetic individuals; (2) To refine and guide a future n-of-1 study design for testing and generating such idiographic hypotheses for personalized management of sleep behavior in particular, and for chronic health conditions more broadly. We initially did not find evidence for an idiographic effect of sleep deprivation, but better-refined post hoc findings indicate that sleep deprivation may have increased BG fluctuations, cravings, and negative emotions. We also introduce an application of mixed-effects models and pancit plots to assess idiographic effects over time.
AB - Abstract: Sleep deprivation is a prevalent and rising health concern, one with known effects on blood glucose (BG) levels, mood, and calorie consumption. However, the mechanisms by which sleep deprivation affects calorie consumption (e.g., measured via self-reported types craved food) are unclear, and may be highly idiographic (i.e., individual specific). Single-case or "n-of-1" randomized trials (N1RT) are useful in exploring such effects by exposing each subject to both sleep deprivation and baseline conditions, thereby characterizing effects specific to that individual. We had two objectives: (1) To test and generate individual-specific N1RT hypotheses of the effects of sleep deprivation on next-day BG level, mood, and food cravings in two non-diabetic individuals; (2) To refine and guide a future n-of-1 study design for testing and generating such idiographic hypotheses for personalized management of sleep behavior in particular, and for chronic health conditions more broadly. We initially did not find evidence for an idiographic effect of sleep deprivation, but better-refined post hoc findings indicate that sleep deprivation may have increased BG fluctuations, cravings, and negative emotions. We also introduce an application of mixed-effects models and pancit plots to assess idiographic effects over time.
U2 - 10.3390/healthcare8010006
DO - 10.3390/healthcare8010006
M3 - Journal article
C2 - 31881721
VL - 8
JO - Healthcare
JF - Healthcare
SN - 2227-9032
IS - 1
M1 - 6
ER -
ID: 234567096