Effects of GH in human muscle and fat

Research output: Contribution to journal › Journal article › Research › peer-review

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Effects of GH in human muscle and fat. / Jørgensen, Jens Otto Lunde; Rubeck, Kristine Zøylner; Nielsen, Thomas Svava; Clasen, Berthil Frederik Forrest; Vendelboe, Mikkel; Hafstrøm, Thomas Krusenstjerna-; Madsen, Michael; Lund, Sten.

In: Pediatric nephrology (Berlin, Germany), Vol. 25, No. 4, 04.2010, p. 705-9.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Jørgensen, JOL, Rubeck, KZ, Nielsen, TS, Clasen, BFF, Vendelboe, M, Hafstrøm, TK, Madsen, M & Lund, S 2010, 'Effects of GH in human muscle and fat', Pediatric nephrology (Berlin, Germany), vol. 25, no. 4, pp. 705-9. https://doi.org/10.1007/s00467-009-1334-3

APA

Jørgensen, J. O. L., Rubeck, K. Z., Nielsen, T. S., Clasen, B. F. F., Vendelboe, M., Hafstrøm, T. K., Madsen, M., & Lund, S. (2010). Effects of GH in human muscle and fat. Pediatric nephrology (Berlin, Germany), 25(4), 705-9. https://doi.org/10.1007/s00467-009-1334-3

Vancouver

Jørgensen JOL, Rubeck KZ, Nielsen TS, Clasen BFF, Vendelboe M, Hafstrøm TK et al. Effects of GH in human muscle and fat. Pediatric nephrology (Berlin, Germany). 2010 Apr;25(4):705-9. https://doi.org/10.1007/s00467-009-1334-3

Author

Jørgensen, Jens Otto Lunde ; Rubeck, Kristine Zøylner ; Nielsen, Thomas Svava ; Clasen, Berthil Frederik Forrest ; Vendelboe, Mikkel ; Hafstrøm, Thomas Krusenstjerna- ; Madsen, Michael ; Lund, Sten. / Effects of GH in human muscle and fat. In: Pediatric nephrology (Berlin, Germany). 2010 ; Vol. 25, No. 4. pp. 705-9.

Bibtex

@article{6832dee321764bf9ba3f0ebcfdb698fa,
title = "Effects of GH in human muscle and fat",
abstract = "Skeletal muscle is the major constituent of lean body mass and a major determinant of energy expenditure both at rest and during physical activity. Growth hormone, in turn, influences muscle mass as well as energy expenditure. Growth hormone substitution in adults increases muscle mass by 5-10%, but part of the effect is attributed to rehydration rather than protein accretion. In addition, GH regulates substrate metabolism in muscle and in particular antagonizes insulin-stimulated glucose disposal. This effect is linked to increased free fatty acid (FFA) flux but the molecular mechanisms remain unclear. During fasting, GH-induced insulin resistance may be favorable by reducing the demand of gluconeogenesis from protein. But in the postprandial phase, GH exposure may compromise glucose tolerance via the same mechanisms. Understanding the mechanisms whereby GH antagonizes insulin-stimulated glucose disposal in muscle is an important future research field with implications for a variety of clinical conditions ranging from malnutrition to obesity and type 2 diabetes.",
keywords = "Adipose Tissue, Fasting, Fatty Acids, Nonesterified, Glucose, Hormone Replacement Therapy, Human Growth Hormone, Humans, Lipid Metabolism, Muscle, Skeletal, Proteins, Signal Transduction",
author = "J{\o}rgensen, {Jens Otto Lunde} and Rubeck, {Kristine Z{\o}ylner} and Nielsen, {Thomas Svava} and Clasen, {Berthil Frederik Forrest} and Mikkel Vendelboe and Hafstr{\o}m, {Thomas Krusenstjerna-} and Michael Madsen and Sten Lund",
year = "2010",
month = apr,
doi = "10.1007/s00467-009-1334-3",
language = "English",
volume = "25",
pages = "705--9",
journal = "Pediatric Nephrology",
issn = "0931-041X",
publisher = "Springer",
number = "4",

}

RIS

TY - JOUR

T1 - Effects of GH in human muscle and fat

AU - Jørgensen, Jens Otto Lunde

AU - Rubeck, Kristine Zøylner

AU - Nielsen, Thomas Svava

AU - Clasen, Berthil Frederik Forrest

AU - Vendelboe, Mikkel

AU - Hafstrøm, Thomas Krusenstjerna-

AU - Madsen, Michael

AU - Lund, Sten

PY - 2010/4

Y1 - 2010/4

N2 - Skeletal muscle is the major constituent of lean body mass and a major determinant of energy expenditure both at rest and during physical activity. Growth hormone, in turn, influences muscle mass as well as energy expenditure. Growth hormone substitution in adults increases muscle mass by 5-10%, but part of the effect is attributed to rehydration rather than protein accretion. In addition, GH regulates substrate metabolism in muscle and in particular antagonizes insulin-stimulated glucose disposal. This effect is linked to increased free fatty acid (FFA) flux but the molecular mechanisms remain unclear. During fasting, GH-induced insulin resistance may be favorable by reducing the demand of gluconeogenesis from protein. But in the postprandial phase, GH exposure may compromise glucose tolerance via the same mechanisms. Understanding the mechanisms whereby GH antagonizes insulin-stimulated glucose disposal in muscle is an important future research field with implications for a variety of clinical conditions ranging from malnutrition to obesity and type 2 diabetes.

AB - Skeletal muscle is the major constituent of lean body mass and a major determinant of energy expenditure both at rest and during physical activity. Growth hormone, in turn, influences muscle mass as well as energy expenditure. Growth hormone substitution in adults increases muscle mass by 5-10%, but part of the effect is attributed to rehydration rather than protein accretion. In addition, GH regulates substrate metabolism in muscle and in particular antagonizes insulin-stimulated glucose disposal. This effect is linked to increased free fatty acid (FFA) flux but the molecular mechanisms remain unclear. During fasting, GH-induced insulin resistance may be favorable by reducing the demand of gluconeogenesis from protein. But in the postprandial phase, GH exposure may compromise glucose tolerance via the same mechanisms. Understanding the mechanisms whereby GH antagonizes insulin-stimulated glucose disposal in muscle is an important future research field with implications for a variety of clinical conditions ranging from malnutrition to obesity and type 2 diabetes.

KW - Adipose Tissue

KW - Fasting

KW - Fatty Acids, Nonesterified

KW - Glucose

KW - Hormone Replacement Therapy

KW - Human Growth Hormone

KW - Humans

KW - Lipid Metabolism

KW - Muscle, Skeletal

KW - Proteins

KW - Signal Transduction

U2 - 10.1007/s00467-009-1334-3

DO - 10.1007/s00467-009-1334-3

M3 - Journal article

C2 - 19902270

VL - 25

SP - 705

EP - 709

JO - Pediatric Nephrology

JF - Pediatric Nephrology

SN - 0931-041X

IS - 4

ER -

ID: 101802092