Effects of exercise on fatty acid composition in skeletal muscle in relation to insulin sensitivity
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Effects of exercise on fatty acid composition in skeletal muscle in relation to insulin sensitivity. / Sjödin, Anders Mikael; Andersson, A; Olsson, Roger; Vessby, B.
In: FASEB Journal, Vol. 11, No. 3, 1997, p. A164.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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TY - ABST
T1 - Effects of exercise on fatty acid composition in skeletal muscle in relation to insulin sensitivity
AU - Sjödin, Anders Mikael
AU - Andersson, A
AU - Olsson, Roger
AU - Vessby, B
PY - 1997
Y1 - 1997
N2 - Nineteen sedentary middle-aged men ate diets with identical fat compositions in amounts calculated to maintain energy balance for 10 weeks. After 4 weeks the subjects were randomly allocated to take part in a daily exercise program (55% of VO2peak, resulting in an increase in energy turnover of 3 MJ/d) or to continue to live a sedentary life for the remaining 6 weeks. After 4 and 10 weeks the fatty acids in muscle phospholipids (m-PL) and triglycerides (m-TG) were determined in a biopsy from the quadriceps muscle and insulin sensitivity was assessed by the euglycemic clamp technique In the trained subjects aerobic capacity, peripheral insulin sensitivity, and percentage of oleic acid (18:1 n-9) in m-PL increased. The proportions of palmitic acid (16:0) and linoleic acid (18:2 n-6) and the sum of n-6 fatty acids in m-PL decreased, while no changes occurred in the fatty acid composition of m-TG In the sedentary subjects no changes were found. We conclude that in middle-aged men the fatty acid composition in m-PL but not in m-TG is influenced by regular low-intensity exercise. In this small group, however, we were unable to show that the above changes correlated to the improved insulin sensitivity.
AB - Nineteen sedentary middle-aged men ate diets with identical fat compositions in amounts calculated to maintain energy balance for 10 weeks. After 4 weeks the subjects were randomly allocated to take part in a daily exercise program (55% of VO2peak, resulting in an increase in energy turnover of 3 MJ/d) or to continue to live a sedentary life for the remaining 6 weeks. After 4 and 10 weeks the fatty acids in muscle phospholipids (m-PL) and triglycerides (m-TG) were determined in a biopsy from the quadriceps muscle and insulin sensitivity was assessed by the euglycemic clamp technique In the trained subjects aerobic capacity, peripheral insulin sensitivity, and percentage of oleic acid (18:1 n-9) in m-PL increased. The proportions of palmitic acid (16:0) and linoleic acid (18:2 n-6) and the sum of n-6 fatty acids in m-PL decreased, while no changes occurred in the fatty acid composition of m-TG In the sedentary subjects no changes were found. We conclude that in middle-aged men the fatty acid composition in m-PL but not in m-TG is influenced by regular low-intensity exercise. In this small group, however, we were unable to show that the above changes correlated to the improved insulin sensitivity.
UR - http://www.scopus.com/inward/record.url?scp=33750130966&partnerID=8YFLogxK
M3 - Conference abstract in journal
AN - SCOPUS:33750130966
VL - 11
SP - A164
JO - F A S E B Journal
JF - F A S E B Journal
SN - 0892-6638
IS - 3
ER -
ID: 211156140