TY - JOUR

T1 - Effectiveness of the targeted hepatitis B vaccination program in Greenland

AU - Børresen, Malene L.

AU - Koch, Anders

AU - Biggar, Robert J.

AU - Ladefoged, Karin

AU - Melbye, Mads

AU - Wohlfahrt, Jan

AU - Krause, Tyra Grove

PY - 2012/2

Y1 - 2012/2

N2 - Objectives. To evaluate the effectiveness of the hepatitis B virus (HBV) vaccination program in Greenland, which targets children born to mothers who are positive for HBV surface antigen (HBsAg), we determined vaccination coverage, levels of postvaccination antibodies, and frequency of breakthrough infections in at-risk children. Methods. We conducted a population-based retrospective cohort study with data from nationwide registries. We identified all children born to HBsAgpositive mothers from 1992 to 2007 and collected data on their HBV vaccination status. In 2008 to 2010, we tested the children for HBV core antibody, HBsAg, and anti-HBsAg antibody (HBsAb). Results. Of 4050 pregnant women, 3.2% were HBsAg positive. Of 207 children born to these women, 20% received no vaccinations, and only 58% received at least 3 vaccinations. At follow-up, HBsAb levels in vaccinated children were much lower than expected, and 8 (6%) of 140 at-risk children had breakthrough infections, with 4 chronically infected (persistently HBsAg positive). Conclusions. The prevention program targeting children at risk for HBV in Greenland is ineffective. HBV vaccination should be included in the universal childhood vaccination program, and postvaccination HBsAb levels should be monitored.

AB - Objectives. To evaluate the effectiveness of the hepatitis B virus (HBV) vaccination program in Greenland, which targets children born to mothers who are positive for HBV surface antigen (HBsAg), we determined vaccination coverage, levels of postvaccination antibodies, and frequency of breakthrough infections in at-risk children. Methods. We conducted a population-based retrospective cohort study with data from nationwide registries. We identified all children born to HBsAgpositive mothers from 1992 to 2007 and collected data on their HBV vaccination status. In 2008 to 2010, we tested the children for HBV core antibody, HBsAg, and anti-HBsAg antibody (HBsAb). Results. Of 4050 pregnant women, 3.2% were HBsAg positive. Of 207 children born to these women, 20% received no vaccinations, and only 58% received at least 3 vaccinations. At follow-up, HBsAb levels in vaccinated children were much lower than expected, and 8 (6%) of 140 at-risk children had breakthrough infections, with 4 chronically infected (persistently HBsAg positive). Conclusions. The prevention program targeting children at risk for HBV in Greenland is ineffective. HBV vaccination should be included in the universal childhood vaccination program, and postvaccination HBsAb levels should be monitored.

UR - http://www.scopus.com/inward/record.url?scp=84857340273&partnerID=8YFLogxK

U2 - 10.2105/AJPH.2011.300239

DO - 10.2105/AJPH.2011.300239

M3 - Journal article

C2 - 21940914

AN - SCOPUS:84857340273

VL - 102

SP - 277

EP - 284

JO - American Journal of Public Health

JF - American Journal of Public Health

SN - 0090-0036

IS - 2

ER -