Effect of milk protein and whey permeate in large-quantity lipid-based nutrient supplement on early child development among children with stunting: A randomized 2 × 2 factorial trial in Uganda
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Effect of milk protein and whey permeate in large-quantity lipid-based nutrient supplement on early child development among children with stunting: A randomized 2 × 2 factorial trial in Uganda. / Mbabazi, Joseph; Pesu, Hannah; Mutumba, Rolland; McCray, Gareth; Michaelsen, Kim F.; Ritz, Christian; Filteau, Suzanne; Briend, André; Mupere, Ezekiel; Grenov, Benedikte; Friis, Henrik; Olsen, Mette Frahm.
In: Nutrients, Vol. 15, No. 12, 2659, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Effect of milk protein and whey permeate in large-quantity lipid-based nutrient supplement on early child development among children with stunting: A randomized 2 × 2 factorial trial in Uganda
AU - Mbabazi, Joseph
AU - Pesu, Hannah
AU - Mutumba, Rolland
AU - McCray, Gareth
AU - Michaelsen, Kim F.
AU - Ritz, Christian
AU - Filteau, Suzanne
AU - Briend, André
AU - Mupere, Ezekiel
AU - Grenov, Benedikte
AU - Friis, Henrik
AU - Olsen, Mette Frahm
N1 - CURIS 2023 NEXS 150
PY - 2023
Y1 - 2023
N2 - Stunting affects 22% children globally, putting them at risk of adverse outcomes including delayed development. We investigated the effect of milk protein (MP) vs. soy and whey permeate (WP) vs. maltodextrin in large-quantity, lipid-based nutrient supplement (LNS), and LNS itself vs. no supplementation, on child development and head circumference among stunted children aged 1-5 years. We conducted a randomized, double-blind, community-based 2 × 2 factorial trial in Uganda (ISRCTN1309319). We randomized 600 children to one of four LNS formulations (~535 kcal/d), with or without MP (n = 299 vs. n = 301) or WP (n = 301 vs. n = 299), for 12 weeks or to no supplementation (n = 150). Child development was assessed using the Malawi Development Assessment Tool. Data were analyzed using linear mixed-effects models. Children had a median [interquartile range] age of 30 [23; 41] months and mean ± standard deviation height-for-age z-score of -3.02 ± 0.74. There were no interactions between MP and WP for any of the outcomes. There was no effect of either MP or WP on any developmental domain. Although LNS itself had no impact on development, it resulted in 0.07 (95%CI: 0.004; 0.14) cm higher head circumference. Neither dairy in LNS, nor LNS in itself, had an effect on development among already stunted children.
AB - Stunting affects 22% children globally, putting them at risk of adverse outcomes including delayed development. We investigated the effect of milk protein (MP) vs. soy and whey permeate (WP) vs. maltodextrin in large-quantity, lipid-based nutrient supplement (LNS), and LNS itself vs. no supplementation, on child development and head circumference among stunted children aged 1-5 years. We conducted a randomized, double-blind, community-based 2 × 2 factorial trial in Uganda (ISRCTN1309319). We randomized 600 children to one of four LNS formulations (~535 kcal/d), with or without MP (n = 299 vs. n = 301) or WP (n = 301 vs. n = 299), for 12 weeks or to no supplementation (n = 150). Child development was assessed using the Malawi Development Assessment Tool. Data were analyzed using linear mixed-effects models. Children had a median [interquartile range] age of 30 [23; 41] months and mean ± standard deviation height-for-age z-score of -3.02 ± 0.74. There were no interactions between MP and WP for any of the outcomes. There was no effect of either MP or WP on any developmental domain. Although LNS itself had no impact on development, it resulted in 0.07 (95%CI: 0.004; 0.14) cm higher head circumference. Neither dairy in LNS, nor LNS in itself, had an effect on development among already stunted children.
KW - Stunting
KW - Child
KW - Infant
KW - Early child development
KW - Whey permeate
KW - Milk Protein
KW - Uganda
KW - Micronutrients
KW - Dietary Supplements
KW - Growth disorders / prevention & control
KW - Nutrient supplements
KW - Lipid-based nutrient supplements
KW - LNS
U2 - 10.3390/nu15122659
DO - 10.3390/nu15122659
M3 - Journal article
C2 - 37375563
VL - 15
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 12
M1 - 2659
ER -
ID: 358719886