Effect of influenza vaccination in solid organ transplant recipients: A nationwide population-based cohort study
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Effect of influenza vaccination in solid organ transplant recipients : A nationwide population-based cohort study. / Harboe, Zitta Barrella; Modin, Daniel; Gustafsson, Finn; Perch, Michael; Gislason, Gunnar; Sorensen, Soren Schwartz; Rasmussen, Allan; Biering-Sorensen, Tor; Nielsen, Susanne Dam.
In: American Journal of Transplantation, Vol. 22, No. 10, 2022, p. 2409-2417.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of influenza vaccination in solid organ transplant recipients
T2 - A nationwide population-based cohort study
AU - Harboe, Zitta Barrella
AU - Modin, Daniel
AU - Gustafsson, Finn
AU - Perch, Michael
AU - Gislason, Gunnar
AU - Sorensen, Soren Schwartz
AU - Rasmussen, Allan
AU - Biering-Sorensen, Tor
AU - Nielsen, Susanne Dam
PY - 2022
Y1 - 2022
N2 - Vaccination can prevent influenza in solid organ transplant (SOT) recipients. Using a modified season-specific approach over nine consecutive influenza seasons, we investigated influenza vaccination coverage and effectiveness in a population-based nationwide cohort study that included all SOT recipients aged >= 18 years who were living in Denmark from December 1, 2007 to April 1, 2016. The primary outcome was the season-specific risk of all-cause pneumonia admission. Secondary outcomes were season-specific influenza-related admission, intensive care unit (ICU) admission, and all-cause mortality. Crude and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. In total, 11 381 person-years of follow-up data were collected from 5745 SOT recipients, 48% of whom were vaccinated. Influenza vaccination was associated with a reduced risk of all-cause pneumonia admission (aHR, 0.83; 95% CI, 0.69-0.99; p = .035) and all-cause mortality (aHR, 0.60; 95% CI, 0.47-0.76; p = .001), but not influenza-related admission (aHR, 0.75; 95% CI, 0.46-1.22; p = .24) or ICU admission (aHR, 0.84; 95% CI, 0.67-1.06; p = .14) during the same season. Despite these benefits, uptake of influenza vaccination among SOT recipients was low. Therefore, annual influenza vaccination needs to be prioritized.
AB - Vaccination can prevent influenza in solid organ transplant (SOT) recipients. Using a modified season-specific approach over nine consecutive influenza seasons, we investigated influenza vaccination coverage and effectiveness in a population-based nationwide cohort study that included all SOT recipients aged >= 18 years who were living in Denmark from December 1, 2007 to April 1, 2016. The primary outcome was the season-specific risk of all-cause pneumonia admission. Secondary outcomes were season-specific influenza-related admission, intensive care unit (ICU) admission, and all-cause mortality. Crude and adjusted hazard ratios (aHRs) with 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. In total, 11 381 person-years of follow-up data were collected from 5745 SOT recipients, 48% of whom were vaccinated. Influenza vaccination was associated with a reduced risk of all-cause pneumonia admission (aHR, 0.83; 95% CI, 0.69-0.99; p = .035) and all-cause mortality (aHR, 0.60; 95% CI, 0.47-0.76; p = .001), but not influenza-related admission (aHR, 0.75; 95% CI, 0.46-1.22; p = .24) or ICU admission (aHR, 0.84; 95% CI, 0.67-1.06; p = .14) during the same season. Despite these benefits, uptake of influenza vaccination among SOT recipients was low. Therefore, annual influenza vaccination needs to be prioritized.
KW - Influenza
KW - pneumonia
KW - SOT
KW - vaccination
KW - DANISH
KW - MORTALITY
KW - HEALTH
KW - SYSTEM
U2 - 10.1111/ajt.17055
DO - 10.1111/ajt.17055
M3 - Journal article
C2 - 35384275
VL - 22
SP - 2409
EP - 2417
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 10
ER -
ID: 314278080