Effect of glucagon-like peptide-2 exposure on bone resorption: Effectiveness of high concentration versus prolonged exposure
Research output: Contribution to journal › Journal article › Research › peer-review
In healthy subjects, subcutaneous injections of GLP-2 have been shown to elicit dose-related decrease in the bone resorption marker, carboxy-terminal telopeptide of type I collagen (CTX), and have been proposed for the treatment of osteoporosis. This study investigated the relation between GLP-2 exposure and decreases in CTX in order to determine whether high concentrations or prolonged exposure was the most effective mode of administration. High GLP-2 concentrations resulted from iv bolus injections, whereas a more protracted stimulation was obtained by subcutaneous injections and the addition of an inhibitor of GLP-2 degradation, a DPP-4 inhibitor, sitagliptin.
Original language | English |
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Journal | Regulatory Peptides |
Volume | 181 |
Pages (from-to) | 4-8 |
Number of pages | 5 |
ISSN | 0167-0115 |
DOIs | |
Publication status | Published - 10 Feb 2013 |
ID: 45840378