Effect of cisplatin on renal haemodynamics and tubular function in the dog kidney.
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Effect of cisplatin on renal haemodynamics and tubular function in the dog kidney. / Daugaard, G; Abildgaard, U; Holstein-Rathlou, N H; Amtorp, O; Leyssac, P P.
In: International Journal of Andrology, Vol. 10, No. 1, 1987, p. 347-51.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effect of cisplatin on renal haemodynamics and tubular function in the dog kidney.
AU - Daugaard, G
AU - Abildgaard, U
AU - Holstein-Rathlou, N H
AU - Amtorp, O
AU - Leyssac, P P
N1 - Keywords: Animals; Cisplatin; Dogs; Erythrocyte Count; Glomerular Filtration Rate; Hematocrit; Hemoglobins; Kidney Tubules; Regional Blood Flow; Renal Circulation
PY - 1987
Y1 - 1987
N2 - Administration of cisplatin (5 mg/kg) to dogs results in polyuric renal failure due initially to a proximal tubular functional impairment. 48-72 h after the cisplatin administration the depressed renal function can be attributed to impairment of proximal as well as distal tubular reabsorptive capacities associated with increased renal vascular resistance. The polyuria seems to be due to the impaired reabsorption rate in the distal nephron segments.
AB - Administration of cisplatin (5 mg/kg) to dogs results in polyuric renal failure due initially to a proximal tubular functional impairment. 48-72 h after the cisplatin administration the depressed renal function can be attributed to impairment of proximal as well as distal tubular reabsorptive capacities associated with increased renal vascular resistance. The polyuria seems to be due to the impaired reabsorption rate in the distal nephron segments.
M3 - Journal article
C2 - 3583422
VL - 10
SP - 347
EP - 351
JO - International Journal of Andrology
JF - International Journal of Andrology
SN - 0105-6263
IS - 1
ER -
ID: 8440337