Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers. / Madsen, P L; Vorstrup, S; Schmidt, J F; Paulson, O B.

In: European Journal of Clinical Pharmacology, Vol. 39, No. 3, 1990, p. 295-7.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Madsen, PL, Vorstrup, S, Schmidt, JF & Paulson, OB 1990, 'Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers', European Journal of Clinical Pharmacology, vol. 39, no. 3, pp. 295-7. https://doi.org/10.1007/BF00315115

APA

Madsen, P. L., Vorstrup, S., Schmidt, J. F., & Paulson, O. B. (1990). Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers. European Journal of Clinical Pharmacology, 39(3), 295-7. https://doi.org/10.1007/BF00315115

Vancouver

Madsen PL, Vorstrup S, Schmidt JF, Paulson OB. Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers. European Journal of Clinical Pharmacology. 1990;39(3):295-7. https://doi.org/10.1007/BF00315115

Author

Madsen, P L ; Vorstrup, S ; Schmidt, J F ; Paulson, O B. / Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers. In: European Journal of Clinical Pharmacology. 1990 ; Vol. 39, No. 3. pp. 295-7.

Bibtex

@article{cad5603d60b043f1ae20c2cc84c72e25,
title = "Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers",
abstract = "The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-venous oxygen difference and CBF. Studies were done before and 1 h after i.v. injection of 5 mg propranolol and after three weeks on oral propranolol 80 mg/d for 1 week and 160 mg/d for 2 weeks. Cerebrovascular CO2 reactivity in terms of the A-V oxygen difference was tested on all three occasions during hypercapnia and hyperventilation. CBF, CMRO2 and cerebrovascular CO2 reactivity remained stable both after acute and after 3 weeks of treatment with propranolol.",
keywords = "Administration, Oral, Adult, Blood Pressure/drug effects, Cerebrovascular Circulation/drug effects, Dose-Response Relationship, Drug, Female, Heart Rate/drug effects, Humans, Injections, Intravenous, Male, Oxygen/metabolism, Propranolol/administration & dosage, Tomography, Emission-Computed, Single-Photon",
author = "Madsen, {P L} and S Vorstrup and Schmidt, {J F} and Paulson, {O B}",
year = "1990",
doi = "10.1007/BF00315115",
language = "English",
volume = "39",
pages = "295--7",
journal = "European Journal of Clinical Pharmacology",
issn = "0031-6970",
publisher = "Springer",
number = "3",

}

RIS

TY - JOUR

T1 - Effect of acute and prolonged treatment with propranolol on cerebral blood flow and cerebral oxygen metabolism in healthy volunteers

AU - Madsen, P L

AU - Vorstrup, S

AU - Schmidt, J F

AU - Paulson, O B

PY - 1990

Y1 - 1990

N2 - The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-venous oxygen difference and CBF. Studies were done before and 1 h after i.v. injection of 5 mg propranolol and after three weeks on oral propranolol 80 mg/d for 1 week and 160 mg/d for 2 weeks. Cerebrovascular CO2 reactivity in terms of the A-V oxygen difference was tested on all three occasions during hypercapnia and hyperventilation. CBF, CMRO2 and cerebrovascular CO2 reactivity remained stable both after acute and after 3 weeks of treatment with propranolol.

AB - The effect of acute and long-term treatment with propranolol on cerebral blood flow (CBF) and the cerebral metabolic rate of oxygen (CMRO2) has been studied in 8 young healthy volunteers. CBF was measured by 133Xe-inhalation and single photon emission computer tomography, and CMRO2 was calculated from the arterio-venous oxygen difference and CBF. Studies were done before and 1 h after i.v. injection of 5 mg propranolol and after three weeks on oral propranolol 80 mg/d for 1 week and 160 mg/d for 2 weeks. Cerebrovascular CO2 reactivity in terms of the A-V oxygen difference was tested on all three occasions during hypercapnia and hyperventilation. CBF, CMRO2 and cerebrovascular CO2 reactivity remained stable both after acute and after 3 weeks of treatment with propranolol.

KW - Administration, Oral

KW - Adult

KW - Blood Pressure/drug effects

KW - Cerebrovascular Circulation/drug effects

KW - Dose-Response Relationship, Drug

KW - Female

KW - Heart Rate/drug effects

KW - Humans

KW - Injections, Intravenous

KW - Male

KW - Oxygen/metabolism

KW - Propranolol/administration & dosage

KW - Tomography, Emission-Computed, Single-Photon

U2 - 10.1007/BF00315115

DO - 10.1007/BF00315115

M3 - Journal article

C2 - 2257870

VL - 39

SP - 295

EP - 297

JO - European Journal of Clinical Pharmacology

JF - European Journal of Clinical Pharmacology

SN - 0031-6970

IS - 3

ER -

ID: 275129497