Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss. / Johansen, Flemming Fryd; Zimmer, J; Diemer, N H.

In: Acta Neuropathologica, Vol. 73, No. 2, 1987, p. 110-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Johansen, FF, Zimmer, J & Diemer, NH 1987, 'Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.', Acta Neuropathologica, vol. 73, no. 2, pp. 110-4.

APA

Johansen, F. F., Zimmer, J., & Diemer, N. H. (1987). Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss. Acta Neuropathologica, 73(2), 110-4.

Vancouver

Johansen FF, Zimmer J, Diemer NH. Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss. Acta Neuropathologica. 1987;73(2):110-4.

Author

Johansen, Flemming Fryd ; Zimmer, J ; Diemer, N H. / Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss. In: Acta Neuropathologica. 1987 ; Vol. 73, No. 2. pp. 110-4.

Bibtex

@article{285a63c05e2b11dd8d9f000ea68e967b,
title = "Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.",
abstract = "Somatostatin (SS)- and cholecystokinin (CCK)-immunopositive cell somata in the rat hippocampus were quantitated at day 1, 2, 3 and 4 after cerebral ischemia. A significant (P less than 0.01) 60%-80% loss of hilar and CA-3c SS neurons took place. No CCK neurons were lost. Damage to SS neurons was significant on the second postischemic day and preceded the delayed loss of CA-1 neurons. We speculate that loss of SS neurons, which presumably innervate the inhibitory GABAergic (gamma-aminobutyric acid) interneurons, may induce hyperactivity stimulating the Ca-1 neurons to death.",
author = "Johansen, {Flemming Fryd} and J Zimmer and Diemer, {N H}",
note = "Keywords: Animals; Brain Ischemia; Cholecystokinin; Hippocampus; Male; Neurons; Rats; Rats, Inbred Strains; Somatostatin",
year = "1987",
language = "English",
volume = "73",
pages = "110--4",
journal = "Acta Neuropathologica",
issn = "0001-6322",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - Early loss of somatostatin neurons in dentate hilus after cerebral ischemia in the rat precedes CA-1 pyramidal cell loss.

AU - Johansen, Flemming Fryd

AU - Zimmer, J

AU - Diemer, N H

N1 - Keywords: Animals; Brain Ischemia; Cholecystokinin; Hippocampus; Male; Neurons; Rats; Rats, Inbred Strains; Somatostatin

PY - 1987

Y1 - 1987

N2 - Somatostatin (SS)- and cholecystokinin (CCK)-immunopositive cell somata in the rat hippocampus were quantitated at day 1, 2, 3 and 4 after cerebral ischemia. A significant (P less than 0.01) 60%-80% loss of hilar and CA-3c SS neurons took place. No CCK neurons were lost. Damage to SS neurons was significant on the second postischemic day and preceded the delayed loss of CA-1 neurons. We speculate that loss of SS neurons, which presumably innervate the inhibitory GABAergic (gamma-aminobutyric acid) interneurons, may induce hyperactivity stimulating the Ca-1 neurons to death.

AB - Somatostatin (SS)- and cholecystokinin (CCK)-immunopositive cell somata in the rat hippocampus were quantitated at day 1, 2, 3 and 4 after cerebral ischemia. A significant (P less than 0.01) 60%-80% loss of hilar and CA-3c SS neurons took place. No CCK neurons were lost. Damage to SS neurons was significant on the second postischemic day and preceded the delayed loss of CA-1 neurons. We speculate that loss of SS neurons, which presumably innervate the inhibitory GABAergic (gamma-aminobutyric acid) interneurons, may induce hyperactivity stimulating the Ca-1 neurons to death.

M3 - Journal article

C2 - 2885998

VL - 73

SP - 110

EP - 114

JO - Acta Neuropathologica

JF - Acta Neuropathologica

SN - 0001-6322

IS - 2

ER -

ID: 5259516